Evidence map›Paper›PMID 37742617›Full record

ArticleNeonatology2023

Placental Histologic Abnormalities and 2-Year Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy.

Fernando F Gonzalez, Emily Voldal, Bryan A Comstock, Dennis E Mayock, Amy M Goodman, Marie-Coralie Cornet, Tai-Wei Wu, Raymond W Redline, Patrick Heagerty, Sandra E Juul and 1 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neonatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Maternal-placental timing profiles of hypoxic-ischemic insult and association with prognosis in neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Fernando F GonzalezDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, California, USA.
Emily VoldalDepartment Biostatistics, University of Washington, Seattle, Washington, USA.
Bryan A ComstockDepartment Biostatistics, University of Washington, Seattle, Washington, USA.
Dennis E MayockDivision of Neonatology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Amy M GoodmanDepartment of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, California, USA.
Marie-Coralie CornetDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, California, USA.
Tai-Wei WuDivision of Neonatology, Fetal and Neonatal Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Raymond W RedlineDepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Patrick HeagertyDepartment Biostatistics, University of Washington, Seattle, Washington, USA.
Sandra E JuulDivision of Neonatology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Yvonne W WuDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, California, USA.
UCSF Benioff Children's Hospital · USChildren's Hospital of Los Angeles · USFred Hutch Cancer Center · USUniversity Hospitals of Cleveland · USUniversity of California, San Francisco · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCCU01NS092764 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JUUL, SANDRA E, WU, YVONNE W · 2016 to 2020
$12.7M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) DCCU01NS092553 · NINDS · UNIVERSITY OF WASHINGTON · PI HEAGERTY, PATRICK J · 2016 to 2020
$1.7M
Maternal Chorioamnionitis and Hypoxic-Ischemic Encephalopathy: The MATCH StudyK23HD109684 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Marie Cornet · 2022 to 2026
$867k
NCATS NIH HHS UL1 TR002319NICHD NIH HHS K23 HD109684NICHD NIH HHS P50 HD103524NINDS NIH HHS L40 NS053125NINDS NIH HHS U01 NS092553NINDS NIH HHS U01 NS092764
6 · The paper itself

Abstract

objectiveWe aimed to examine the association between placental abnormalities and neurodevelopmental outcomes in a multicenter cohort of newborn infants with hypoxic-ischemic encephalopathy (HIE) that underwent therapeutic hypothermia. We hypothesized that subjects with acute placental abnormalities would have reduced risk of death or neurodevelopmental impairment (NDI) at 2 years of age after undergoing therapeutic hypothermia compared to subjects without acute placental changes. STUDY

designAmong 500 subjects born at ≥36 weeks gestation with moderate or severe HIE enrolled in the High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) Trial, a placental pathologist blinded to clinical information reviewed clinical pathology reports to determine the presence of acute only, chronic only, or both acute and chronic histologic abnormalities. We calculated adjusted relative risks (aRRs) for associations between placental pathologic abnormalities and death or NDI at age 2 years, adjusting for HIE severity, treatment assignment, and site.

result321/500 subjects (64%) had available placental pathology reports. Placental abnormalities were characterized as acute only (20%), chronic only (21%), both acute and chronic (43%), and none (15%). The risk of death or NDI was not statistically different between subjects with and without an acute placental abnormality (46 vs. 53%, aRR 1.1, 95% confidence interval (CI): 0.9, 1.4). Subjects with two or more chronic lesions were more likely to have an adverse outcome than subjects with no chronic abnormalities, though this did not reach statistical significance (55 vs. 45%, aRR 1.24, 95% CI: 0.99, 1.56).

conclusionPlacental pathologic findings were not independently associated with risk of death or NDI in subjects with HIE. The relationship between multiple chronic placental lesions and HIE outcomes deserves further study.

Indexed as

Asphyxia NeonatorumHypothermia, InducedHypoxia-Ischemia, BrainAsphyxiaChildChild, PreschoolDevelopmental DisabilitiesFemaleHumansInfantInfant, NewbornPlacentaPregnancyErythropoietinHypothermiaHypoxic-ischemic encephalopathyOutcomesPerinatal asphyxiaPlacenta

Identifiers

PMID37742617
PMCPMC10711751
OpenAlexW4387001876

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.