ArticlePediatric neurology2023
The Impact of Sociodemographic Disadvantage on Cognitive Outcomes in Children With Newly Diagnosed Seizures and Their Unaffected Siblings Over 36 Months.
Article in Pediatric neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- The network neuropsychology of neighborhood deprivation in juvenile myoclonic epilepsy.Scientific reports · 2026Article
- The role of social context in cognitive and neurobehavioural outcomes in epilepsy.Nature reviews. Neurology · 2026Review
- General mental ability (Spearman's g) in Juvenile Myoclonic Epilepsy.Epilepsia open · 2025Article
- Sleep Disturbance Phenotype Trajectories and Associated Multimorbidity in Children With New-Onset Seizures Over 36 Months.Pediatric neurology · 2025Article
- Cognitive and brain health in juvenile myoclonic epilepsy: Role of social determinants of health.Epilepsia · 2025Article
- Stratifying cognitive and behavioral comorbidities in children with new-onset seizures - The influence of sociodemographic disadvantage.Epilepsy & behavior : E&B · 2025Article
- Latent cognitive phenotypes in juvenile myoclonic epilepsy: Clinical, sociodemographic, and neuroimaging associations.Epilepsia · 2025Article
- Long-term characterization of behavior phenotypes in children with seizures: Analytic approach matters.Epilepsia · 2025Article
- Home-ics: how experiences of the home impact biology and child neurodevelopmental outcomes.Pediatric research · 2024Review
- Individual- and community-level social determinants of health are associated with cognition in older adults with focal epilepsy.Epilepsy & behavior : E&B · 2024Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAccumulating evidence indicates that children with newly diagnosed epilepsy have comorbidities including cognitive challenges. Research investigating comorbidities has focused on clinical epilepsy characteristics and neurobiological/genetic correlates. The role that sociodemographic disadvantage (SD) may play has received less attention. We investigated the role of SD in cognitive status in youth with newly diagnosed epilepsy over a follow-up of 36 months to determine the degree, extent, and duration of the role of disadvantage.
methodsA total of 289 children (six to 16 years) within six weeks of their first seizure along with 167 siblings underwent comprehensive neuropsychological assessments (intelligence, language, memory, executive function, processing speed, and academic achievement) at baseline, 18 months later, and at 36 months from baseline. Baseline demographic information (race, caregivers education, household income, and parental marital status), clinical epilepsy characteristics (e.g., age of onset), and magnetic resonance imaging (MRI) and electroencephalographic (EEG) information was collected.
resultsAn SD index was computed for each family and categorized into four groups by level of disadvantage. In children and siblings, the least disadvantaged group exhibited the highest Full-Scale IQ, neuropsychological factor scores, and academic performances, whereas the most disadvantaged showed the polar opposite with the worst performances across all tests. Findings remained stable and significant over 36 months. Linear regression analyses indicated that disadvantage was a more constant and stable predictor of cognitive and academic performance over time compared with clinical epilepsy characteristics and MRI/EEG abnormalities.
conclusionsThis study indicates the strong association between SD and cognitive/academic performance in children with newly diagnosed epilepsy and their siblings is significant and predictive of three-year cognitive outcomes.
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