ArticleCell reports2023
ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m
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Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
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Who cites it
32 citing papers in PubMed, 40 citations in OpenAlex.
- Dietary Supplementation of Glutamate Alleviates LPS-Induced Intestinal Injury Associated with mAnimals : an open access journal from MDPI · 2026Article
- ALKBH5 activates creatine-driven thermogenesis by stabilizing CKB mRNA in response to cold.Nature metabolism · 2026Article
- Plasma Exosomes Associated with Growth Divergence in High-Density Cultured Grass Carp (International journal of molecular sciences · 2026Article
- ALKBH5 modulates COL5A1 mRNA stability via m6A demethylation to promote tobacco carcinogen NNK-induced lung cancer occurrence and progression.Journal of advanced research · 2026Article
- OGDH mediates α-ketoglutarate-induced follicular development and antioxidative response by interacting with CAT/SOD2.Biological research · 2026Article
- The N6-Methyladenosine RNA Demethylase AlkB Homolog 5 (ALKBH5) in Metabolic Diseases: Molecular Mechanisms and Pharmacological Implications-A Review.Biomolecules · 2026Review
- Targeting the Glutamine Transporter SLC1A5 Enhances Sensitivity of Acute Myeloid Leukemia to MLN4924.Biomedicines · 2026Article
- RMzyme: regulations of RNA-modifying enzymes in humans.Signal transduction and targeted therapy · 2026Article
- DDX24 modulates angiogenesis by promoting CCR4-NOT complex-dependent mRNA decay.Nucleic acids research · 2026Article
- Nat10-mediated ac4C epitranscriptomics orchestrates hematopoietic stem/progenitor cell fate determination via translation control.Science advances · 2026Article
- RNA modifications in cancer stem cells: molecular mechanisms and targeted therapeutic strategies.Frontiers in cell and developmental biology · 2026Review
- Loss of Alkbh5 enhances AT2 cell differentiation and alveolar repair across diverse injury models via mInternational journal of biological sciences · 2026Article
- Targeting of the mNature communications · 2025Article
- Reconstruction of hematopoietic stem cell nichesMaterials today. Bio · 2025Review
- ALKBH5 demethylation modification of SE-lncRNA ZMIZ1-AS1 promotes FGFR1-mediated proliferation and invasive metastasis in osteosarcoma.Cellular and molecular life sciences : CMLS · 2025Article
- mCells · 2025Review
- Biomolecular condensates in immune cell fate.Nature reviews. Immunology · 2025Review
- Global analysis by LC-MS/MS ofRNA (New York, N.Y.) · 2025Article
- Reprogramming patient-induced pluripotent stem cell-specific retinal organoids for deciphering epigenetic modifications of RNA methylation.Journal of the Chinese Medical Association : JCMA · 2025Article
- The role of mFrontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
21 authors at 7 institutions in 4 countries.
Yimeng GaoSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: gaoym@tongji.edu.cn.
Joshua T ZimmerDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06511, USA; Institute for Biomolecular Design and Discovery, Yale University, West Haven, CT 06516, USA.
Radovan VasicSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Medicine, University of Toronto, Toronto, ON M5S3H2, Canada.
Chengyang LiuSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Rana GbyliSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Shu-Jian ZhengInstitute for Biomolecular Design and Discovery, Yale University, West Haven, CT 06516, USA; Department of Chemistry, Yale University, New Haven, CT 06520, USA.
Amisha PatelSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Wei LiuSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Zhihong QiSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Yaping LiSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Raman NelakantiDepartment of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Yuanbin SongSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Giulia BianconSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA.
Andrew Z XiaoDepartment of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06520, USA.
Sarah SlavoffDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06511, USA; Institute for Biomolecular Design and Discovery, Yale University, West Haven, CT 06516, USA; Department of Chemistry, Yale University, New Haven, CT 06520, USA.
Richard G KibbeyDepartment of Internal Medicine, Yale University, New Haven, CT 06520, USA; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06520, USA.
Richard A FlavellDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Matthew D SimonDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06511, USA; Institute for Biomolecular Design and Discovery, Yale University, West Haven, CT 06516, USA.
Toma TebaldiSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.
Hua-Bing LiShanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Stephanie HaleneSection of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: stephanie.halene@yale.edu.
Yale Cancer Center · USYale University · USHoward Hughes Medical Institute · USShanghai Jiao Tong University · CNSun Yat-sen University · CNUniversity of Toronto · CAUniversity of Trento · IT
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0MYale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7MTargeting Defective DNA Damage Response Pathways in IDH1/2-mutant AMLR01CA266604 · NCI · YALE UNIVERSITY · PI Ranjit Bindra, Stephanie Halene · 2022 to 2026
$3.3MModeling myelodysplasiaR01CA253981 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI GRIMES, H. LEIGHTON, HALENE, STEPHANIE · 2021 to 2025
$2.9MRevealing the dynamics of RNA metabolism with nucleotide recoding chemistryR01GM137117 · NIGMS · YALE UNIVERSITY · PI Matthew David Simon · 2020 to 2026
$2.6MThe role of mutant splicing factor SRSF2 in MyelodysplasiaR01DK102792 · NIDDK · YALE UNIVERSITY · PI HALENE, STEPHANIE · 2016 to 2019
$1.5MThe role of m6A RNA modification as modulator of dsRNA induced cell-intrinsic innate immune responses in hematopoiesisR01DK124788 · NIDDK · YALE UNIVERSITY · PI HALENE, STEPHANIE · 2021 to 2023
$884kFlow cytometer for high-parameter analysesS10OD026996 · OD · YALE UNIVERSITY · PI HABERMAN, ANN M · 2019 to 2019
$596kHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA253981NCI NIH HHS R01 CA266604NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK102792NIDDK NIH HHS R01 DK124788NIDDK NIH HHS U54 DK106857NIGMS NIH HHS R01 GM137117NIH HHS S10 OD026996
Abstract
N
Indexed as
LeukemiaRNAAlkB Homolog 5, RNA DemethylaseAnimalsEnergy MetabolismHematopoietic Stem CellsHumansMiceRNA StabilityALKBH5 protein, humanALKBH5 protein, mouseAlkB Homolog 5, RNA DemethylaseRNAALKBH5ATP productionCP: Molecular biologyCP: Stem cell researchenergy metabolismhematopoietic stem and progenitor cellsleukemiam(6)A modificationoxidative phosphorylationOXPHOSRNA stabilitystress hematopoiesis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.