Evidence map›Paper›PMID 37742189›Full record

ArticleCell reports2023

Rules and mechanisms governing G protein coupling selectivity of GPCRs.

Ikuo Masuho, Ryoji Kise, Pablo Gainza, Ee Von Moo, Xiaona Li, Ryosuke Tany, Hideko Wakasugi-Masuho, Bruno E Correia, Kirill A Martemyanov

Abstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
  2. Review
  3. G-protein regulatory network governs receptor internalization dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  13. The Retinal Light Response Is Modulated by an mGluR5-Mediated Retrograde Signal from ON-Bipolar Cells to Photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ikuo MasuhoDepartment of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA. Electronic address: ikuo.masuho@sanfordhealth.org.
Ryoji KisePediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Pablo GainzaLaboratory of Protein Design and Immunoengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne and Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Ee Von MooDepartment of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA.
Xiaona LiDepartment of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA.
Ryosuke TanyPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Hideko Wakasugi-MasuhoDepartment of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Bruno E CorreiaLaboratory of Protein Design and Immunoengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne and Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Kirill A MartemyanovDepartment of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL 33458, USA. Electronic address: kmartemyanov@ufl.edu.

Funding

Regulation of Striatal Signaling by RGS ProteinsR01DA036596 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kirill A. Martemyanov · 2014 to 2026
$6.5M
Orphan Receptors in Regulation of Neuronal G Protein SignalingR01MH105482 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kirill A. Martemyanov · 2015 to 2026
$6.1M
NIDA NIH HHS R01 DA036596NIMH NIH HHS R01 MH105482
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: G

Indexed as

GTP-Binding ProteinsReceptors, G-Protein-CoupledAlgorithmsCarrier ProteinsSignal TransductionCarrier ProteinsGTP-Binding ProteinsReceptors, G-Protein-CoupledBRET assayclassificationCP: Cell biologyGEF activitygenetic variationGPCRG proteinGαsignaling biassystems biology

Identifiers

PMID37742189
PMCPMC10842385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.