ArticleCell reports2023
Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Spontaneous and stimulus-driven arousal produce distinct acetylcholine dynamics across sensory and prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- The representation of omitted sounds in the mouse auditory cortex.Nature communications · 2026Article
- Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Chronic Loud Noise-Biochemical and Ultrastructural Alterations in Auditory and Limbic Regions of the Rat Brain.BioMed research international · 2026Article
- Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.bioRxiv : the preprint server for biology · 2025Article
- Objective autonomic signatures of tinnitus and sound sensitivity disorders.Science translational medicine · 2025Article
- Experience-driven development of decision-related representations in the auditory cortex.EMBO reports · 2025Article
- Beat-based dancing to music has evolutionary foundations in advanced vocal learning.BMC neuroscience · 2024Review
- Cortical determinants of loudness perception and auditory hypersensitivity.bioRxiv : the preprint server for biology · 2024Article
- Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities in mice.Current biology : CB · 2024Article
- The human pupil and face encode sound affect and provide objective signatures of tinnitus and auditory hypersensitivity disorders.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The amygdala, cholinergic basal forebrain, and higher-order auditory cortex (HO-AC) regulate brain-wide plasticity underlying auditory threat learning. Here, we perform multi-regional extracellular recordings and optical measurements of acetylcholine (ACh) release to characterize the development of discriminative plasticity within and between these brain regions as mice acquire and recall auditory threat memories. Spiking responses are potentiated for sounds paired with shock (CS+) in the lateral amygdala (LA) and optogenetically identified corticoamygdalar projection neurons, although not in neighboring HO-AC units. Spike- or optogenetically triggered local field potentials reveal enhanced corticofugal-but not corticopetal-functional coupling between HO-AC and LA during threat memory recall that is correlated with pupil-indexed memory strength. We also note robust sound-evoked ACh release that rapidly potentiates for the CS+ in LA but habituates across sessions in HO-AC. These findings highlight a distributed and cooperative plasticity in LA inputs as mice learn to reappraise neutral stimuli as possible threats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.