ArticleBMC urology2023
Ae index is an independent predictor of kidney stone recurrence in overweight and obese patients.
Article in BMC urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 10 citations in OpenAlex.
- Risk factors for kidney stone recurrence and early prediction models: a systematic review and meta-analysis.Translational andrology and urology · 2026Article
- A lower LDL-c/ApoB ratio is associated with an increased prevalence of gallstones in the regional Chinese adult population, according to a retrospective, propensity-matched analysis.Frontiers in physiology · 2026Article
- Association between the apolipoprotein B/albumin ratio and the risk of kidney stones in adults.Frontiers in physiology · 2026Article
- Elevated ApoB/ApoA ratio is associated with recurrent kidney stones in a Chinese adult population: a retrospective, propensity-matched analysis.European journal of medical research · 2025Article
- Bioinformatic Analysis of Oxalate-Degrading Enzymes in Probiotics: A Systematic Genome-Scale and Structural Survey.Microorganisms · 2025Article
- Development and validation of a machine learning-based prediction model for urinary calculi recurrence.Urolithiasis · 2025Article
- Associations between clinical, biochemical, and nutritional factors in kidney stone formation and recurrence.Urolithiasis · 2025Article
- Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones.Diseases (Basel, Switzerland) · 2025Article
- Establishment and application of a nomogram diagram for predicting calcium oxalate stones in patients with urinary tract stones.Urolithiasis · 2024Article
- WWI: a novel lens on kidney stone risk prediction.World journal of urology · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
backgroundFinding some convenient and economical indicators to initially screen overweight and obese patients at high risk of kidney stone recurrence can help them prevent stone recurrence with lower medical cost. The purpose of this article is to determine the clinical value of Ae index (Apo B × 1000/eGFR) as an independent predictor for kidney stone recurrence in overweight and obese populations.
methodsWe queried the electronic medical records of patients with kidney stone operated at our hospital from March 2016 to March 2022, and selected BMI ≥ 25 kg/m
resultsUnivariate analysis found that Apo B (OR:8.376,95%CI:3.093-22.680), Creatinine (OR:1.012,95%CI:1.003-1.021), Cystatin C(OR:2.747,95%CI:1.369-5.508), LDL-C (OR:1.588,95%CI:1.182-2.134), TC (OR:1.543,95%CI:1.198-1.988) were positively associated, eGFR (OR:0.980,95%CI:0.970-0.991) was negatively associated with kidney stone recurrence. And multivariate logistic regression analysis suggested that Apo B (OR:11.028, 95%CI:3.917-31.047) and eGFR (OR:0.976, 95%CI:0.965-0.988) were the most significant factors. Then we calculated Ae index and analyzed it, the sensitivity was 74.26% and the specificity was 60.00%, higher than either individual variable. Its smoothed curve revealed a non-linear relationship between them with the inflection point of 9.16. And the OR on the left side of the inflection point was 1.574 (95% CI: 1.228-2.018), whereas the OR on the right side of the inflection point was 1.088 (95% CI: 1.007-1.177).
conclusionsAe index is an easily calculated and obtained index that has some predictive value for kidney stone recurrence in overweight and obese patients, which is of interest.
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