ReviewInsights into imaging2023
Factors influencing the outcome of volumetry tools for pulmonary nodule analysis: a systematic review and attempted meta-analysis.
Review in Insights into imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Towards optimized CT lung cancer screening scan protocols.The British journal of radiology · 2026Article
- Lung nodule detection and potential impact on guideline-based management: a retrospective post-market evaluation of three commercial software systems.European radiology · 2026Article
- Rationale for the Nodule Management Protocol of the Australian National Lung Cancer Screening Program.Journal of medical imaging and radiation oncology · 2026Review
- CT acquisition protocols in lung cancer screening: implications for guideline development from a worldwide survey.Insights into imaging · 2026Article
- Artificial intelligence as an independent reader of risk-dominant lung nodules: influence of CT reconstruction parameters.European radiology · 2026Article
- Construction and validation of a prediction model for malignant pulmonary nodules based on imaging, demographic, and laboratory features.Frontiers in oncology · 2026Article
- Effect of slice thickness on quantitative analysis of interstitial lung disease: a retrospective volumetric chest CT study.La Radiologia medica · 2025Article
- Performance Evaluation of Four Deep Learning-Based CAD Systems and Manual Reading for Pulmonary Nodules Detection, Volume Measurement, and Lung-RADS Classification Under Varying Radiation Doses and Reconstruction Methods.Diagnostics (Basel, Switzerland) · 2025Article
- Lung nodule localization and size estimation on chest tomosynthesis.Journal of medical imaging (Bellingham, Wash.) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Health systems worldwide are implementing lung cancer screening programmes to identify early-stage lung cancer and maximise patient survival. Volumetry is recommended for follow-up of pulmonary nodules and outperforms other measurement methods. However, volumetry is known to be influenced by multiple factors. The objectives of this systematic review (PROSPERO CRD42022370233) are to summarise the current knowledge regarding factors that influence volumetry tools used in the analysis of pulmonary nodules, assess for significant clinical impact, identify gaps in current knowledge and suggest future research. Five databases (Medline, Scopus, Journals@Ovid, Embase and Emcare) were searched on the 21st of September, 2022, and 137 original research studies were included, explicitly testing the potential impact of influencing factors on the outcome of volumetry tools. The summary of these studies is tabulated, and a narrative review is provided. A subset of studies (n = 16) reporting clinical significance were selected, and their results were combined, if appropriate, using meta-analysis. Factors with clinical significance include the segmentation algorithm, quality of the segmentation, slice thickness, the level of inspiration for solid nodules, and the reconstruction algorithm and kernel in subsolid nodules. Although there is a large body of evidence in this field, it is unclear how to apply the results from these studies in clinical practice as most studies do not test for clinical relevance. The meta-analysis did not improve our understanding due to the small number and heterogeneity of studies testing for clinical significance. CRITICAL RELEVANCE STATEMENT: Many studies have investigated the influencing factors of pulmonary nodule volumetry, but only 11% of these questioned their clinical relevance in their management. The heterogeneity among these studies presents a challenge in consolidating results and clinical application of the evidence. KEY POINTS: • Factors influencing the volumetry of pulmonary nodules have been extensively investigated. • Just 11% of studies test clinical significance (wrongly diagnosing growth). • Nodule size interacts with most other influencing factors (especially for smaller nodules). • Heterogeneity among studies makes comparison and consolidation of results challenging. • Future research should focus on clinical applicability, screening, and updated technology.
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