Evidence map›Paper›PMID 37741869›Full record

ArticleNature communications2023

Structural basis for calcium-stimulating pore formation of Vibrio α-hemolysin.

Yu-Chuan Chiu, Min-Chi Yeh, Chun-Hsiung Wang, Yu-An Chen, Hsiang Chang, Han-You Lin, Meng-Chiao Ho, Shih-Ming Lin

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yu-Chuan Chiu *Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Min-Chi Yeh *Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Chun-Hsiung WangInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Yu-An ChenDepartment of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Hsiang ChangDepartment of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0009-0007-8764-5547
Han-You LinDepartment of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
Meng-Chiao HoInstitute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-5424-4524
Shih-Ming LinDepartment of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan. smlin@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-9672-8316
National Cheng Kung University · TWInstitute of Biological Chemistry, Academia Sinica · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vibrio α-hemolysins (αHLs) are β-pore-forming toxins secreted by Vibrio pathogens, crucial for the facilitation of bacterial infections through host cell lysis. These toxins are produced as inactive precursors, requiring proteolytic maturation and membrane association for activation within host tissues. Here, we investigate Vibrio campbellii αHL (VcαHL), and establish that its hemolytic activity is significantly stimulated by calcium ions, with an EC

Indexed as

Bacterial ToxinsHemolysin ProteinsCalciumCell MembraneCryoelectron MicroscopyIonsBacterial ToxinsCalciumHemolysin ProteinsIons

Identifiers

PMID37741869
PMCPMC10517994
OpenAlexW4386988949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.