Evidence map›Paper›PMID 37741821›Full record

ArticleScientific reports2023

An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model.

Alejandra Gonzalez Calle, Javad Paknahad, Dimitrios Pollalis, Pragya Kosta, Biju Thomas, Ben Yi Tew, Bodour Salhia, Stan Louie, Gianluca Lazzi, Mark Humayun

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Alejandra Gonzalez Calle *Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Javad Paknahad *USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
Dimitrios PollalisDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Pragya KostaUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
Biju ThomasUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
Ben Yi TewUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
Bodour SalhiaUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
Stan LouieUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
Gianluca LazziUSC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
Mark HumayunDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. humayun@usc.edu.
University of Southern California · USLAC+USC Medical Center · USSouthern California Eye Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are characterized by unrelenting neuronal death. However, electrical stimulation has been shown to induce neuroprotective changes in the retina capable of slowing down the progression of retinal blindness. In this work, a multi-scale computational model and modeling platform were used to design electrical stimulation strategies to better target the bipolar cells (BCs), that along with photoreceptors are affected at the early stage of retinal degenerative diseases. Our computational findings revealed that biphasic stimulus pulses of long pulse duration could decrease the activation threshold of BCs, and the differential stimulus threshold between ganglion cells (RGCs) and BCs, offering the potential of targeting the BCs during the early phase of degeneration. In vivo experiments were performed to evaluate the electrode placement and parameters found to target bipolar cells and evaluate the safety and efficacy of the treatment. Results indicate that the proposed transcorneal Electrical Stimulation (TES) strategy can attenuate retinal degeneration in a Royal College of Surgeon (RCS) rodent model, offering the potential to translate this work to clinical practice.

Indexed as

Macular DegenerationRetinal DegenerationAnimalsElectric StimulationHumansModels, AnimalRetina

Identifiers

PMID37741821
PMCPMC10517961
OpenAlexW4386986051

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.