ArticleNature communications2023
Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Ectomesenchymal identity emerges via relief of Twist1 transcript destabilisation.Nature communications · 2026Article
- Unveiling the Prevalence and Surgical Burden of Neurocristopathies: A Scoping Review and Statistical Analysis.Research square · 2026Article
- Ectomesenchyme contributes to epidermal stem cell formation through mesenchymal-to-epithelial transition.Nature communications · 2026Article
- Neural crest gene regulatory networks as drivers of development, diversification and disease.Nature reviews. Molecular cell biology · 2026Review
- CD271 Identifies a Subpopulation with Enhanced Neural-like Potential Within Wharton Jelly Derived Mesenchymal Stem/Stromal Cells.International journal of molecular sciences · 2026Article
- A spatial and temporal atlas of tubulin isotype expression during neural crest EMT.bioRxiv : the preprint server for biology · 2026Article
- Dynamic and non-uniform expression of key transcription factors provides insights into the emergence of neural crest cells at the neural plate border.Development (Cambridge, England) · 2026Article
- NR6A1 is essential for neural crest cell specification, formation and survival.Nature communications · 2026Article
- The ChickenGTEx portal: a pan-tissue catalogue of regulatory variants shaping transcriptomic and phenotypic diversity.Nucleic acids research · 2026Article
- A dual role for GLI3 signaling in neural crest development.Development (Cambridge, England) · 2026Article
- Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates.Frontiers in cell and developmental biology · 2026Review
- Integrated Single-cell Analysis Uncovers Regulatory Logic of Cranial Ectoderm Development.bioRxiv : the preprint server for biology · 2025Article
- Ectomesenchymal identity emerges via relief ofbioRxiv : the preprint server for biology · 2025Article
- Article
- Krüppel-like factors play essential roles in regulating pluripotency and the formation of neural crest stem cells.Development (Cambridge, England) · 2025Article
- Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.Trends in neurosciences · 2025Review
- Spatiotemporal characterization of cyclooxygenase pathway enzymes during vertebrate embryonic development.Developmental biology · 2025Article
- Neural crest precursors from the skin are the primary source of directly reprogrammed neurons.Stem cell reports · 2024Article
- Insights into the molecular characteristics of embryonic cranial neural crest cells and their derived mesenchymal cell pools.Communications biology · 2024Article
- Shared features of blastula and neural crest stem cells evolved at the base of vertebrates.Nature ecology & evolution · 2024Article
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Abstract
The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally high stem-cell potential to generate mesodermal- and endodermal-like derivatives is obtained. Here, we monitor transcriptional changes from gastrulation to neurulation using single-cell-Multiplex-Spatial-Transcriptomics (scMST) complemented with RNA-sequencing. We show maintenance of pluripotency-like signature (Nanog, Oct4/PouV, Klf4-positive) in undecided pan-ectodermal stem-cells spanning the entire ectoderm late during neurulation with ectodermal patterning completed only at the end of neurulation when the pluripotency-like signature becomes restricted to NC, challenging our understanding of gastrulation. Furthermore, broad ectodermal pluripotency-like signature is found at multiple axial levels unrelated to the NC lineage the cells later commit to, suggesting a general role in stemness enhancement and proposing a mechanism by which the NC acquires its ability to form derivatives beyond "ectodermal-capacity" in chick and mouse embryos.
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