Evidence map›Paper›PMID 37740736›Full record

ArticleCellular and molecular life sciences : CMLS2023

Stem cell antigen-1

Tingting Tao, Luping Du, Peng Teng, Yan Guo, Xuyang Wang, Yanhua Hu, Haige Zhao, Qingbo Xu, Liang Ma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. CD34Histology and histopathology · 2026
    Review
  2. Review
  3. From Cell to Gene: Deciphering the Mechanism of Heart Failure With Single-Cell Sequencing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tingting Tao *Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Luping Du *Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Peng TengDepartment of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Yan GuoDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Xuyang WangDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Yanhua HuDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Haige ZhaoDepartment of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Qingbo XuDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China. qingbo_xu@zju.edu.cn.ORCID http://orcid.org/0000-0003-2474-8155
Liang MaDepartment of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China. ml1402@zju.edu.cn.
First Affiliated Hospital Zhejiang University · CN

Funding

National Natural Science Foundation of China 31830039National Natural Science Foundation of China 82030008National Natural Science Foundation of China 82270409Science and Technology Program of Zhejiang Province 2023C03087
6 · The paper itself

Abstract

aimsMesenchymal stem cells (MSCs) present in the heart cannot differentiate into cardiomyocytes, but may play a role in pathological conditions. Therefore, the aim of this study was to scrutinise the role and mechanism of MSC differentiation in vivo during heart failure. METHODS AND

resultsWe performed single-cell RNA sequencing of total non-cardiomyocytes from murine and adult human hearts. By analysing the transcriptomes of single cells, we illustrated the dynamics of the cell landscape during the progression of heart hypertrophy, including those of stem cell antigen-1 (Sca1)

conclusionsOur study describes the cellular landscape of hypertrophic hearts and reveals that fibroblasts derived from Sca1

Indexed as

Cell DifferentiationFibroblastsFibrosisHeart FailureAnimalsAntigens, LyAtaxin-1HumansMaleMembrane ProteinsMesenchymal Stem CellsMiceMice, Inbred C57BLMyocardiumMyocytes, CardiacSingle-Cell AnalysisAntigens, LyAtaxin-1Ly6a protein, mouseMembrane ProteinsGenetic lineage tracingMyocardial fibrosisSca1+ cellsSingle-cell RNA sequencingTransverse aortic constriction

Identifiers

PMID37740736
PMCPMC11073062
OpenAlexW4386981608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.