ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Shape-Morphing Photoresponsive Hydrogels Reveal Dynamic Topographical Conditioning of Fibroblasts.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- A Wet-and-Dry Research Model: Unveiling Biomechanics in Odontoblast Polarization.International endodontic journal · 2026Article
- Photo-guided azopolymer hydrogel actuators.Light, science & applications · 2026Article
- Mechanically graded granular scaffolds for osteochondral tissue engineering.Biomaterials advances · 2026Article
- Trainable Hydrogels: Mechanistic Principles, Training Strategies, and Frontier Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- Live-shaping of hydrogel thin films with light.Nature communications · 2026Article
- Photoswitchable Cross-Linking in Polymer Gels: Effects on Surface Creasing and Network Relaxation during Swelling.Macromolecules · 2026Article
- Light-Responsive Surface Topographies Modulate Macrophage Immune Responses Through Dynamic Mechanical Cues.Macromolecular bioscience · 2026Article
- Revisiting the biophysical aspects of extracellular-matrix-mimicking hydrogels: what cells seeBiomaterials science · 2025Review
- Signals from the extracellular matrix: Region- and sex-specificity in cardiac aging.Current opinion in cell biology · 2025Review
- The mechanobiology of fibroblast activation in disease.APL bioengineering · 2025Review
- Light-Responsive Liquid Crystal Surface Topographies for Dynamic Stimulation of Cells.ACS applied materials & interfaces · 2025Article
- Dynamic substrate topographies drive actin- and vimentin-mediated nuclear mechanoprotection events in human fibroblasts.BMC biology · 2025Article
- [Effects of cell area on single odontoblast polarization and differentiation via microarray technology].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Article
- Hydrogel-Based Continuum Soft Robots.Gels (Basel, Switzerland) · 2025Review
- Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation.Nature communications · 2025Article
- Hierarchically Structured and Tunable Hydrogel Patches: Design, Characterization, and Application.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Three-Dimensional Printed Cell-Adaptable Nanocolloidal Hydrogel Induces Endogenous Osteogenesis for Bone Repair.Biomaterials research · 2025Article
- Advanced Multifunctional Hydrogels for Enhanced Wound Healing through Ultra-Fast Selenol-SAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Shape-Morphing Photoresponsive Hydrogels Reveal Dynamic Topographical Conditioning of Fibroblasts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The extracellular environment defines a physical boundary condition with which cells interact. However, to date, cell response to geometrical environmental cues is largely studied in static settings, which fails to capture the spatiotemporally varying cues cells receive in native tissues. Here, a photoresponsive spiropyran-based hydrogel is presented as a dynamic, cell-compatible, and reconfigurable substrate. Local stimulation with blue light (455 nm) alters hydrogel swelling, resulting in on-demand reversible micrometer-scale changes in surface topography within 15 min, allowing investigation into cell response to controlled geometry actuations. At short term (1 h after actuation), fibroblasts respond to multiple rounds of recurring topographical changes by reorganizing their nucleus and focal adhesions (FA). FAs form primarily at the dynamic regions of the hydrogel; however, this propensity is abolished when the topography is reconfigured from grooves to pits, demonstrating that topographical changes dynamically condition fibroblasts. Further, this dynamic conditioning is found to be associated with long-term (72 h) maintenance of focal adhesions and epigenetic modifications. Overall, this study offers a new approach to dissect the dynamic interplay between cells and their microenvironment and shines a new light on the cell's ability to adapt to topographical changes through FA-based mechanotransduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.