Evidence map›Paper›PMID 37740551›Full record

ArticleThe Journal of infectious diseases2024

High-Resolution Plasma Metabolomics Identifies Alterations in Fatty Acid, Energy, and Micronutrient Metabolism in Adults Across the Leprosy Spectrum.

Jessica K Fairley, José A Ferreira, Lucia A O Fraga, Sandra Lyon, Thales M Valadão Cardoso, Victor Campos Boson, Ana Carolina Madureira Nunes, Eloisa H Medeiros Cinha, Lorena B P de Oliveira, Erica B Magueta Silva and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Jessica K FairleyDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-4086-9272
José A FerreiraFaculdade da Saúde e Écologia Humana, FASEH, Vespasiano, Minas Gerais, Brazil.
Lucia A O FragaDepartment of Health Sciences, Universidade Federal de Juiz de Fora, Governador Valadares, Minas Gerais, Brazil.
Sandra LyonFaculdade da Saúde e Écologia Humana, FASEH, Vespasiano, Minas Gerais, Brazil.
Thales M Valadão CardosoFaculdade da Saúde e Écologia Humana, FASEH, Vespasiano, Minas Gerais, Brazil.
Victor Campos BosonFaculdade da Saúde e Écologia Humana, FASEH, Vespasiano, Minas Gerais, Brazil.
Ana Carolina Madureira NunesFaculdade da Saúde e Écologia Humana, FASEH, Vespasiano, Minas Gerais, Brazil.
Eloisa H Medeiros CinhaDepartment of Health Sciences, Universidade Federal de Juiz de Fora, Governador Valadares, Minas Gerais, Brazil.
Lorena B P de OliveiraDepartment of Health Sciences, Universidade Federal de Juiz de Fora, Governador Valadares, Minas Gerais, Brazil.
Erica B Magueta SilvaDepartment of Health Sciences, Universidade Federal de Juiz de Fora, Governador Valadares, Minas Gerais, Brazil.
Pedro H F MarçalDepartment of Health Sciences, Universidade Federal de Juiz de Fora, Governador Valadares, Minas Gerais, Brazil.
Alexandre C BrancoCentro de Referência em Doenças Endêmicas e Programs Especiais, Governador Valadares, Minas Gerais, Brazil.
Maria Aparecida F GrossiFaculdade da Saúde e Écologia Humana, FASEH, Vespasiano, Minas Gerais, Brazil.
Dean P JonesDivision of Pulmonary, Critical Care, and Allergy, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-2090-0677
Thomas R ZieglerDivision of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Jeffrey M CollinsDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Universidade Federal de Juiz de Fora · BREmory University · USFundação Hospitalar do Estado de Minas Gerais · BRVale (Brazil) · BR

Funding

High resolution plasma metabolomics to identify biomarkers of tuberculosisK23AI144040 · NIAID · EMORY UNIVERSITY · PI COLLINS, JEFFREY M · 2019 to 2023
$911k
Patient Oriented Research In Clinical NutritionK24DK096574 · NIDDK · EMORY UNIVERSITY · PI ZIEGLER, THOMAS R · 2012 to 2016
$888k
Identifying Risk Factors for Leprosy Transmission Related to Co-infections, Unsafe WASH and Undernutrition Using Novel Serologic Multiplex and High Resolution Metabolomic AssaysR01AI149527 · NIAID · EMORY UNIVERSITY · PI FAIRLEY, JESSICA K. · 2020 to 2023
$624k
High-Resolution Plasma Metabolomic Profiling to Identify Biomarkers for Tuberculosis Disease and Response to TherapyR21AI130918 · NIAID · EMORY UNIVERSITY · PI JONES, DEAN PAUL, ZIEGLER, THOMAS R · 2017 to 2018
$442k
NIAID NIH HHS K23 AI144040NIAID NIH HHS R01 AI149527NIAID NIH HHS R21 AI130918NIDDK NIH HHS K24 DK096574NIH HHS R01 AI149527
6 · The paper itself

Abstract

backgroundHigh-resolution metabolomics (HRM) is an innovative tool to study challenging infectious diseases like leprosy, where the pathogen cannot be grown with standard methods. Here, we use HRM to better understand associations between disease manifestations, nutrition, and host metabolism.

methodsFrom 2018 to 2019, adults with leprosy and controls were recruited in Minas Gerais, Brazil. Plasma metabolites were detected using an established HRM workflow and characterized by accurate mass, mass to charge ratio m/z and retention time. The mummichog informatics package compared metabolic pathways between cases and controls and between multibacillary (MB) and paucibacillary (PB) leprosy. Additionally, select individual metabolites were quantified and compared.

resultsThirty-nine cases (62% MB and 38% PB) and 25 controls were enrolled. We found differences (P < .05) in several metabolic pathways, including fatty acid metabolism, carnitine shuttle, retinol, vitamin D3, and C-21 steroid metabolism, between cases and controls with lower retinol and associated metabolites in cases. Between MB and PB, leukotrienes, prostaglandins, tryptophan, and cortisol were all found to be lower in MB (P < .05). DISCUSSION: Metabolites associated with several nutrient-related metabolic pathways appeared differentially regulated in leprosy, especially MB versus PB. This pilot study demonstrates the metabolic interdependency of these pathways, which may play a role in the pathophysiology of disease.

Indexed as

LeprosyMicronutrientsAdultFatty AcidsHumansMycobacterium lepraePilot ProjectsVitamin AFatty AcidsMicronutrientsVitamin Acarnitineenergy metabolismfatty acidsHansen's diseasehigh-resolution metabolomicsleprosymetabolismMycobacterium lepraenutritionretinoltryptophanvitamin D

Identifiers

PMID37740551
PMCPMC11011203
OpenAlexW4386979690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.