Evidence map›Paper›PMID 37740145›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2023

Delayed-Onset Organ/Space Surgical Site Infection Worsens Prognosis in High-Risk Stage II and III Colorectal Cancer.

Jun Okui, Kohei Shigeta, Yujin Kato, Shodai Mizuno, Kiyoaki Sugiura, Yuki Seo, Jumpei Nakadai, Hideo Baba, Hiroto Kikuchi, Akira Hirata and 8 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jun OkuiDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Kohei ShigetaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan. ohlkoh@gmail.com.ORCID 0000-0003-1596-4200
Yujin KatoDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Shodai MizunoDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Kiyoaki SugiuraDepartment of Surgery, Japan Red Cross Ashikaga Hospital, Tochigi, Japan.
Yuki SeoDepartment of Surgery, Japan Red Cross Ashikaga Hospital, Tochigi, Japan.
Jumpei NakadaiDepartment of Gastrointestinal Surgery, Saitama City Hospital, Saitama, Japan.
Hideo BabaDepartment of Gastrointestinal Surgery, Saitama City Hospital, Saitama, Japan.
Hiroto KikuchiDepartment of Surgery, Hiratsuka City Hospital, Hiratsuka, Kanagawa, Japan.
Akira HirataDepartment of Surgery, Hiratsuka City Hospital, Hiratsuka, Kanagawa, Japan.
Akitsugu MakinoDepartment of Surgery, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
Takayuki KondoDepartment of Surgery, Kawasaki Municipal Hospital, Kawasaki, Kanagawa, Japan.
Shimpei MatsuiDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Ryo SeishimaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Koji OkabayashiDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Hideaki ObaraDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Yasunori SatoDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is unclear how early- and delayed-onset organ/space surgical site infections (SSIs) affect the long-term prognosis of patients with colorectal cancer, who are potential candidates for adjuvant chemotherapy. This study aimed to investigate the association between the timing of SSI onset and clinical outcome.

methodsThis retrospective, multicenter cohort study evaluated patients who were diagnosed with high-risk stage II or III colorectal cancer and underwent elective surgery between 2010 and 2020. Five-year recurrence-free survival (RFS) was the primary endpoint and was compared between early SSI, delayed SSI (divided based on the median date of SSI onset), and non-SSI groups.

resultsA total of 2,065 patients were included. Organ/space SSI was diagnosed in 91 patients (4.4%), with a median onset of 6 days after surgery. The early-onset SSI group had a higher proportion of patients with Clavien-Dindo grade ≥IIIb SSI than the delayed-onset SSI. Patients who received adjuvant chemotherapy (AC) had earlier organ/space SSI onset than those who did not. The adjusted hazard ratio of 5-year RFS in the delayed-onset SSI was 2.58 (95% confidence interval: 1.43-4.65; p = 0.002): higher than that in the early-onset SSI, with the non-SSI as the reference.

conclusionsDelayed-onset organ/space SSI worsened long-term prognosis compared to early-onset, and this may be due to delayed initiation of AC. Patients who are clinically suspected of having lymph node metastasis might need additional intervention to prevent delays in commencing AC due to the delayed SSI.

Indexed as

Colorectal NeoplasmsSurgical Wound InfectionCohort StudiesHumansPrognosisRetrospective StudiesRisk FactorsAbdominal abscessAdjuvantAnastomotic leakChemotherapyColorectal neoplasmsSurgical wound infection

Identifiers

PMID37740145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.