Evidence map›Paper›PMID 37740102›Full record

ArticleInflammation2024

Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis.

Li He, Lan Liu, Dan Xu, Ying Tu, Chenling Yang, Mei Zhang, Hongyun Wang, Xiang Nong

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. [Role of m6A methylation modification in photoaging and ultraviolet-induced skin cancers].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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  5. The mCells · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Li He *Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming City, Yunnan Province, 650032, China.
Lan Liu *Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming City, Yunnan Province, 650032, China.
Dan XuDepartment of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming City, Yunnan Province, 650032, China.
Ying TuDepartment of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming City, Yunnan Province, 650032, China.
Chenling YangDepartment of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming City, Yunnan Province, 650032, China.
Mei ZhangDepartment of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming City, Yunnan Province, 650032, China.
Hongyun WangDepartment of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming City, Yunnan Province, 650032, China.
Xiang NongDepartment of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming City, Yunnan Province, 650032, China. nx7011@126.com.
Kunming Medical University · CNFirst Affiliated Hospital of Kunming Medical University · CN

Funding

Program for Innovative Research Team in Ministry of Education of China IRT17-R49
6 · The paper itself

Abstract

Pyroptosis is an inflammatory programmed cell death (PCD) and is reported to be associated with N6-methyladenosine (m6A) modification. This study aimed to investigate the mechanism of m6A demethylase AlkB homolog 5 (ALKBH5) in pyroptosis in the process of chronic actinic dermatitis (CAD). Changes of m6A-related genes were evaluated between CAD and normal samples using quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Human keratinocytes (HaCaT cells) exposed to ultraviolet B (UVB; 10, 20, and 30 mJ/cm

Indexed as

Photosensitivity DisordersPyroptosisAdenosineAlkB Homolog 5, RNA DemethylaseAnimalsCaspase 1CytokinesHumansInterleukin-18Interleukin-1betaMiceRNA, Small InterferingTumor Necrosis Factor-alphaAdenosineALKBH5 protein, humanALKBH5 protein, mouseAlkB Homolog 5, RNA DemethylaseCaspase 1CytokinesInterleukin-18Interleukin-1betaRNA, Small InterferingTumor Necrosis Factor-alphaALKBH5chronic actinic dermatitisinflammationpyroptosisultraviolet B.

Identifiers

PMID37740102
OpenAlexW4386979625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.