Evidence map›Paper›PMID 37740093›Full record

SynthesisEuropean child & adolescent psychiatry2024

Systematic review: emotion dysregulation and challenging behavior interventions for children and adolescents on the autism spectrum with graded key evidence-based strategy recommendations.

Heather J Nuske, Amanda V Young, Farzana Y Khan, Emma H Palermo, Bukola Ajanaku, Melanie Pellecchia, Giacomo Vivanti, Carla A Mazefsky, Lauren Brookman-Frazee, James C McPartland and 2 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European child & adolescent psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Research Review: Emotion regulation in individuals with intellectual disability - an integrative review.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Review
  4. Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Strategies for optimal management of pediatric acute agitation in emergency settings.Journal of the American College of Emergency Physicians open · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Heather J NuskePenn Center for Mental Health, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Floor 3, Philadelphia, PA, 19104, USA. heather.nuske@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-6618-3768
Amanda V YoungPenn Center for Mental Health, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Floor 3, Philadelphia, PA, 19104, USA.
Farzana Y KhanPenn Center for Mental Health, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Floor 3, Philadelphia, PA, 19104, USA.
Emma H PalermoPenn Center for Mental Health, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Floor 3, Philadelphia, PA, 19104, USA.
Bukola AjanakuPenn Center for Mental Health, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Floor 3, Philadelphia, PA, 19104, USA.
Melanie PellecchiaPenn Center for Mental Health, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Floor 3, Philadelphia, PA, 19104, USA.
Giacomo VivantiA. J. Drexel Autism Institute, Drexel University, Philadelphia, USA.
Carla A MazefskyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, USA.
Lauren Brookman-FrazeeDepartment of Psychiatry, University of California San Diego, San Diego, USA.
James C McPartlandYale Child Study Center, Yale University, New Haven, USA.
Matthew S GoodwinDepartment of Health Sciences, Northeastern University, Boston, USA.
David S MandellPenn Center for Mental Health, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Floor 3, Philadelphia, PA, 19104, USA.
University of Pennsylvania · USColumbia University · USDrexel University · USMayo Clinic · USNortheastern University · USPenn Center for AIDS Research · USUniversity of California San Diego · USUniversity of Pittsburgh · USYale University · US

Funding

The Autism Biomarkers Consortium for Clinical TrialsU19MH108206 · NIMH · YALE UNIVERSITY · PI DAWSON, GERALDINE · 2015 to 2024
$68.8M
Reducing Challenging Behaviors In Children With Autism Through Digital HealthK01MH120509 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI NUSKE, HEATHER J · 2020 to 2024
$773k
NIMH NIH HHS K01 MH120509NIMH NIH HHS K01MH120509NIMH NIH HHS U19 MH108206
6 · The paper itself

Abstract

Challenging behavior, such as aggression, is highly prevalent in children and adolescents on the autism spectrum and can have a devastating impact. Previous reviews of challenging behavior interventions did not include interventions targeting emotion dysregulation, a common cause of challenging behavior. We reviewed emotion dysregulation and challenging behavior interventions for preschoolers to adolescents to determine which evidence-based strategies have the most empirical support for reducing/preventing emotion dysregulation/challenging behavior. We reviewed 95 studies, including 29 group and 66 single case designs. We excluded non-behavioral/psychosocial interventions and those targeting internalizing symptoms only. We applied a coding system to identify discrete strategies based on autism practice guidelines with the addition of strategies common in childhood mental health disorders, and an evidence grading system. Strategies with the highest quality evidence (multiple randomized controlled trials with low bias risk) were Parent-Implemented Intervention, Emotion Regulation Training, Reinforcement, Visual Supports, Cognitive Behavioral/Instructional Strategies and Antecedent-Based Interventions. Regarding outcomes, most studies included challenging behavior measures, while few included emotion dysregulation measures. This review highlights the importance of teaching emotion regulation skills explicitly, positively reinforcing replacement/alternative behaviors, using visuals and metacognition, addressing stressors proactively, and involving parents. It also calls for more rigorously designed studies and for including emotion dysregulation as an outcome/mediator in future trials.

Indexed as

Autism Spectrum DisorderEmotional RegulationAdolescentChildChild, PreschoolHumansProblem BehaviorChallenging behaviorEmotion dysregulationEvidence-based strategiesExternalizing symptomsNational Clearinghouse on Autism Evidence and Practice (NCAEP)

Identifiers

PMID37740093
OpenAlexW4386954418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.