Evidence map›Paper›PMID 37739887›Full record

ReviewVaccine2023

The role of tissue resident memory CD4 T cells in Salmonella infection: Implications for future vaccines.

Claire E Depew, Stephen J McSorley

Open access · hybridAbstract readReview
In one paragraph

Review in Vaccine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Claire E DepewDepartment of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA. Electronic address: cdepew@ucdavis.edu.
Stephen J McSorleyDepartment of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA. Electronic address: sjmcsorley@ucdavis.edu.
University of California, Davis · US

Funding

Animal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3M
Target antigen identification to improve Salmonella vaccinationR01AI139410 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STEPHEN J MCSORLEY, Renee M Tsolis · 2018 to 2026
$2.9M
Salmonella-specific Th1 cell function and residenceR01AI139047 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCSORLEY, STEPHEN J · 2019 to 2023
$1.9M
Vaccine induction of Salmonella-specific Th1 memory cellsR21AI187632 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCSORLEY, STEPHEN J · 2024 to 2025
$417k
NIAID NIH HHS R01 AI139047NIAID NIH HHS R01 AI139410NIAID NIH HHS R21 AI187632NIAID NIH HHS T32 AI060555
6 · The paper itself

Abstract

Salmonella infections cause a wide range of intestinal and systemic disease that affects global human health. While some vaccines are available, they do not mitigate the impact of Salmonella on endemic areas. Research using Salmonella mouse models has revealed the important role of CD4 T cells and antibody in the development of protective immunity against Salmonella infection. Recent work points to a critical role for hepatic tissue-resident memory lymphocytes in naturally acquired immunity to systemic infection. Thus, understanding the genesis and function of this Salmonella-specific population is an important objective and is the primary focus of this review. Greater understanding of how these memory lymphocytes contribute to bacterial elimination could suggest new approaches to vaccination against an important human pathogen.

Indexed as

CD4 T cellsSubunit vaccinesSystemic Salmonella infectionTissue resident memory T cellsVaccines

Identifiers

PMID37739887
PMCPMC12184790
OpenAlexW4386898158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.