Evidence map›Paper›PMID 37739795›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Acute Ethanol Modulates Synaptic Inhibition in the Basolateral Amygdala via Rapid NLRP3 Inflammasome Activation and Regulates Anxiety-Like Behavior in Rats.

Soumyabrata Munshi, Lucas Albrechet-Souza, Raoni Conceição Dos-Santos, Claire E Stelly, Maria E Secci, Nicholas W Gilpin, Jeffrey G Tasker

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Sex differences in neural circuits driving binge-like drinking: a female-specific role for an amygdalo-striatal pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Anxiolytic Effects ofFoods (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Soumyabrata MunshiDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118.
Lucas Albrechet-SouzaDepartment of Cell Biology and Anatomy, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.
Raoni Conceição Dos-SantosDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118.
Claire E StellyDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118.
Maria E SecciDepartment of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.
Nicholas W GilpinDepartment of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.ORCID 0000-0001-8901-8917
Jeffrey G TaskerDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118 tasker@tulane.edu.ORCID 0000-0003-1977-4199
Tulane University · USSoutheast Louisiana Veterans Health Care System · USLouisiana State University Health Sciences Center New Orleans · US

Funding

Traumatic stress increases alcohol drinking via endocannabinoid disinhibition of basolateral amygdalaR01AA026531 · NIAAA · LSU HEALTH SCIENCES CENTER · PI GILPIN, NICHOLAS WARREN, TASKER, JEFFREY G · 2017 to 2021
$1.9M
Targeting Melanocortin-4 Receptors to Reduce Pain in U.S. VeteransI01BX003451 · VA · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · PI GILPIN, NICHOLAS WARREN · 2017 to 2025
–
Role of amygdala inhibitory circuit neuromodulation in stress disordersI01BX005118 · VA · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · PI TASKER, JEFFREY G · 2021 to 2025
–
BLRD VA I01 BX003451BLRD VA I01 BX005118NIAAA NIH HHS R01 AA026531
6 · The paper itself

Abstract

Chronic alcohol exposure leads to a neuroinflammatory response involving activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome and proinflammatory cytokine production. Acute ethanol (EtOH) exposure activates GABAergic synapses in the central and basolateral amygdala (BLA)

Indexed as

AnxietyBasolateral Nuclear ComplexEthanolAnimalsFemalegamma-Aminobutyric AcidInflammasomesMaleNLR Family, Pyrin Domain-Containing 3 ProteinNucleotidesParvalbuminsRatsToll-Like Receptor 4Ethanolgamma-Aminobutyric AcidInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNucleotidesParvalbuminsToll-Like Receptor 4alcoholcytokineGABAIL-1βneuroimmuneparvalbumin

Identifiers

PMID37739795
PMCPMC10669756
OpenAlexW4386952465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.