Evidence map›Paper›PMID 37739763›Full record

ArticleThe Journal of investigative dermatology2023

Applications of Human Pluripotent Stem Cell-Derived Skin Organoids in Dermatology.

Aaron Gabriel W Sandoval, Kelly Y Gim, Jennifer T Huang, Karl R Koehler

Abstract read
In one paragraph

Article in The Journal of investigative dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. TotalInternational journal of molecular sciences · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Human-Induced Pluripotent Stem Cells in Plastic and Reconstructive Surgery.International journal of molecular sciences · 2024
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aaron Gabriel W SandovalHarvard Medical School, Boston, Massachusetts, USA.
Kelly Y GimDepartment of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Plastic & Oral Surgery, Boston Children's Hospital, Boston, Massachusetts, USA; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Jennifer T HuangDermatology Section, Division of Immunology, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA.
Karl R KoehlerDepartment of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Plastic & Oral Surgery, Boston Children's Hospital, Boston, Massachusetts, USA; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: karl.koehler@childrens.harvard.edu.

Funding

Generation of human skin organoids from pluripotency (Admin Supplement)R01AR075018 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI Karl Russell Koehler · 2019 to 2026
$3.6M
NIAMS NIH HHS R01 AR075018
6 · The paper itself

Abstract

Pluripotent stem cells have the potential to become any cell type, and recently, they have been used to create organoids that can recapitulate several pertinent features of human organs. Skin organoids have been developed that possess many of the crucial accessory organs, including hair follicles, sebaceous glands, nerves, fat, and melanocytes. These skin organoids present the opportunity to study skin development and disease as well as perform screens to identify new drug candidates. In the future, skin organoids might augment clinical practice by serving as source material for transplantation to treat wounds or other conditions. Nevertheless, several limitations, such as the lengthy differentiation protocol, which can result in heterogeneous products, must first be addressed before the full potential of skin organoids can be realized. The purpose of this article is to provide a broad overview of skin organoids so that a broader audience can become familiar with this technology, which has important implications for dermatologic research and medicine.

Indexed as

DermatologyPluripotent Stem CellsHumansOrganoidsSebaceous GlandsSkin

Identifiers

PMID37739763
PMCPMC10518840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.