Evidence map›Paper›PMID 37739576›Full record

ReviewThe Lancet. Neurology2023

Long-term risk of cardiovascular disease after traumatic brain injury: screening and prevention.

Saef Izzy, Rachel Grashow, Farid Radmanesh, Patrick Chen, Herman Taylor, Rita Formisano, Fiona Wilson, Meagan Wasfy, Aaron Baggish, Ross Zafonte

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 54 citations in OpenAlex.

  1. Nanozyme-based therapeutic strategies for traumatic brain injury.International journal of pharmaceutics: X · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Saef IzzyDivisions of Stroke, Cerebrovascular, and Critical Care Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Football Players Health Study at Harvard University, Boston, MA, USA.
Rachel GrashowDepartment of Environmental Health, T H Chan School of Public Health, Harvard University, Boston, MA, USA; Football Players Health Study at Harvard University, Boston, MA, USA.
Farid RadmaneshDivisions of Stroke, Cerebrovascular, and Critical Care Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurology, Division of Neurocritical Care, University of New Mexico, Albuquerque, NM, USA.
Patrick ChenDepartment of Neurology, University of California Irvine, Orange, CA, USA.
Herman TaylorFootball Players Health Study at Harvard University, Boston, MA, USA; Morehouse School of Medicine, Atlanta, GA, USA.
Rita FormisanoLucia Foundation, Rome, Italy.
Fiona WilsonSchool of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Meagan WasfyHarvard Medical School, Boston, MA, USA; Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.
Aaron BaggishFootball Players Health Study at Harvard University, Boston, MA, USA; Institute for Sport Science and Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
Ross ZafonteHarvard Medical School, Boston, MA, USA; Football Players Health Study at Harvard University, Boston, MA, USA; Spaulding Rehabilitation Hospital, Department of Physical Medicine and Rehabilitation, Massachusetts General Hospital, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: rzafonte@mgh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USFondazione Santa Lucia · ITMassachusetts General Hospital · USMorehouse School of Medicine · USTrinity College Dublin · IEUniversity of California, Irvine · US

Funding

Targeting CNS Neuroinflammation in Traumatic Brain Injury by Nasal Anti-CD3K08NS123503 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Saef Izzy · 2022 to 2026
$1.2M
NINDS NIH HHS K08 NS123503
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is highly prevalent among individuals participating in contact sports, military personnel, and in the general population. Although it is well known that brain injury can cause neurological and psychiatric complications, evidence from studies on individuals exposed to a single or repetitive brain injuries suggests an understudied association between TBI and the risk of developing chronic cardiovascular diseases and risk factors for cardiovascular disease. Several studies have shown that people without pre-existing comorbidities who sustain a TBI have a significantly higher risk of developing chronic cardiovascular disease, than people without TBI. Similar observations made in military and professional American-style football cohorts suggest causal pathways through which modifiable cardiovascular risk factors might mediate the relationship between brain injury and chronic neurological diseases. A better understanding of cardiovascular disease risk after TBI combined with a proactive, targeted screening programme might mitigate long-term morbidity and mortality in individuals with TBI, and improve their quality of life.

Indexed as

Brain InjuriesBrain Injuries, TraumaticCardiovascular DiseasesFootballHumansQuality of Life

Identifiers

PMID37739576
PMCPMC10863697
OpenAlexW4386906055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.