Evidence map›Paper›PMID 37739463›Full record

ArticleBMJ open2023

Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct.

Susanne Hempel, Margie Danz, Karen A Robinson, Maria Bolshakova, Jesus Rodriguez, Alanna Mears, Cindy Pham, Sachi Yagyu, Aneesa Motala, Danica Tolentino and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Susanne HempelSouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USA susanne.hempel@med.usc.edu.ORCID 0000-0003-1597-5110
Margie DanzSouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USA.
Karen A RobinsonDivision of Health Science Informatics, John Hopkins Medicine, Baltimore, Maryland, USA.
Maria BolshakovaSouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USA.
Jesus RodriguezSouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USA.
Alanna MearsSouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USA.
Cindy PhamSouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USA.
Sachi YagyuSouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USA.
Aneesa MotalaSouthern California Evidence Review Center, University of Southern California, Los Angeles, California, USA.
Danica TolentinoKeck School of Medicine, University of Southern California, Los Angeles, California, USA.
Omid AkbariMolecular Microbiology and Immunology, University of Southern California, Los Angeles, California, USA.
Jill JohnstonKeck School of Medicine, University of Southern California, Los Angeles, California, USA.
University of Southern California · USJohns Hopkins University · US

Funding

Study the link of autophagy dysfunction to allergic and neutrophilic asthma onsetR01HL151493 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2020 to 2024
$3.6M
Role of TNF receptor 2 on Pulmonary Group 2 Innate Lymphoid CellsR01HL159804 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2022 to 2025
$3.0M
Transcriptional and metabolomic regulation of IL-10 in pulmonary ILC2sR01AI169687 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OMID AKBARI · 2022 to 2026
$2.1M
NHLBI NIH HHS R01 HL151493NHLBI NIH HHS R01 HL159804NIAID NIH HHS R01 AI169687
6 · The paper itself

Abstract

introductionMultiple chemical sensitivity (MCS) has been characterised by reported adverse responses to environmental exposures of common chemical agents (eg, perfumes, paint, cleaning products and other inhaled or ingested agents) in low doses considered non-toxic for the general population. There is currently no consensus on whether MCS can be established as a distinct disorder. METHODS AND ANALYSIS: The scoping review of the literature will be guided by five questions: How is MCS defined and which diagnostic criteria have been proposed? What methods are used to report prevalence and incidence estimates of MCS? What are the characteristics of the body of scientific evidence that addresses whether MCS is a distinct disorder or syndrome? What underlying mechanisms for MCS have been proposed in the scientific literature? Which treatment and management approaches for MCS have been evaluated in empirical research studies? We will conduct a comprehensive search in 14 research databases. Citation screening will be supported by machine learning algorithms. Two independent reviewers will assess eligibility of full-text publications against prespecified criteria. Data abstraction will support concise evidence tables. A formal consultation exercise will elicit input regarding the review results and presentation. The existing research evidence will be documented in a user-friendly visualisation in the format of an evidence map. ETHICS AND DISSEMINATION: Determined to be exempt from review (UP-22-00516). Results will be disseminated through a journal manuscript and data will be publicly accessible through an online data repository. REGISTRATION DETAILS: The protocol is registered in Open Science Framework (osf.io/4a3wu).

Indexed as

Multiple Chemical SensitivityAlgorithmsConcept FormationConsensusEnvironmental ExposureHumansScoping Reviews as TopicGENERAL MEDICINE (see Internal Medicine)INTERNAL MEDICINESystematic Review

Identifiers

PMID37739463
PMCPMC10533706
OpenAlexW4386969764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.