Evidence map›Paper›PMID 37739407›Full record

ArticleJournal of the American Chemical Society2023

Helicase Activity Modulation with On-Demand Light-Based Conformational Control.

Dmitriy Bobrovnikov, Monika A Makurath, Clara H Wolfe, Yann R Chemla, Taekjip Ha

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. DNA-Regulated Multi-Protein Complement Control.Journal of the American Chemical Society · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dmitriy BobrovnikovDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.
Monika A MakurathDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Clara H WolfeDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.ORCID 0000-0003-4862-8254
Yann R ChemlaDepartment of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Taekjip HaDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.ORCID 0000-0003-2195-6258

Funding

Biochemistry, Cellular and Molecular Biology Program: JHU BioGREAT (Biomedical Graduate REsiliency & Adaptability Training)T32GM144272 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Takanari Inoue · 2022 to 2026
$5.4M
Single Molecule Studies of Nucleic Acids RemodelingR35GM122569 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Taekjip Ha · 2017 to 2026
$3.5M
Mechanisms of DNA helicases and their regulationR35GM144125 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Yann R. Chemla · 2022 to 2026
$1.9M
Mechanisms of regulation of DNA repair helicasesR01GM120353 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHEMLA, YANN R. · 2016 to 2020
$1.4M
NIGMS NIH HHS R01 GM120353NIGMS NIH HHS R35 GM122569NIGMS NIH HHS R35 GM144125NIGMS NIH HHS T32 GM144272
6 · The paper itself

Abstract

Engineering a protein variant with a desired role relies on deep knowledge of the relationship between a protein's native structure and function. Using our structural understanding of a regulatory subdomain found in a family of DNA helicases, we engineered novel helicases for which the subdomain orientation is designed to switch between unwinding-inactive and -active conformations upon

Indexed as

DNA HelicasesDNA, Single-StrandedMolecular ConformationDNA HelicasesDNA, Single-Stranded

Identifiers

PMID37739407
PMCPMC10557133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.