Evidence map›Paper›PMID 37738677›Full record

ArticleNeuro-oncology2024

Brain tumors in United States military veterans.

John R Bihn, Gino Cioffi, Kristin A Waite, Carol Kruchko, Corey Neff, Mackenzie Price, Quinn T Ostrom, Kaitlin N Swinnerton, Danne C Elbers, Michael A Mooney and 12 more

Open access · hybridAbstract read
In one paragraph

Article in Neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 1 country.

John R BihnVA Boston Healthcare System, Boston, Massachusetts, USA.
Gino CioffiTrans Divisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0002-3296-8652
Kristin A WaiteTrans Divisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Carol KruchkoCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.ORCID 0000-0001-7212-035X
Corey NeffCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Mackenzie PriceCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Quinn T OstromCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Kaitlin N SwinnertonVA Boston Healthcare System, Boston, Massachusetts, USA.
Danne C ElbersVA Boston Healthcare System, Boston, Massachusetts, USA.
Michael A MooneyVA Boston Healthcare System, Boston, Massachusetts, USA.
Jacob RachlinVA Boston Healthcare System, Boston, Massachusetts, USA.
Thor D SteinVA Boston Healthcare System, Boston, Massachusetts, USA.
Mary T BrophyVA Boston Healthcare System, Boston, Massachusetts, USA.
Nhan V DoVA Boston Healthcare System, Boston, Massachusetts, USA.
Ryan E FergusonVA Boston Healthcare System, Boston, Massachusetts, USA.
David S PriemerDepartment of Pathology, Uniformed Services University School of Medicine, Bethesda, Maryland, USA.
Daniel P PerlDepartment of Pathology, Uniformed Services University School of Medicine, Bethesda, Maryland, USA.
Richard A HickmanHenry M. Jackson Foundation for The Advancement of Military Medicine, Bethesda, Maryland, USA.
Burt NaborsDepartment of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jennifer RusieckiDepartment of Preventive Medicine and Biostatistics, Uniformed Services University School of Medicine, Bethesda, Maryland, USA.
Jill S Barnholtz-SloanTrans Divisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Nathanael R FillmoreVA Boston Healthcare System, Boston, Massachusetts, USA.
Boston University · USCentral Brain Tumor Registry of the United States · USDuke University · USHenry M. Jackson Foundation · USVA Boston Healthcare System · USHarvard University · USBrigham and Women's Hospital · USUniformed Services University of the Health Sciences · USUniversity of Alabama at Birmingham · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
CDC HHS 75D30119C06056NCI NIH HHS 75N91022P00827NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundComprehensive analysis of brain tumor incidence and survival in the Veteran population has been lacking.

methodsVeteran data were obtained from the Veterans Health Administration (VHA) Medical Centers via VHA Corporate Data Warehouse. Brain tumor statistics on the overall US population were generated from the Central Brain Tumor Registry of the US data. Cases were individuals (≥18 years) with a primary brain tumor, diagnosed between 2004 and 2018. The average annual age-adjusted incidence rates (AAIR) and 95% confidence intervals were estimated per 100 000 population and Kaplan-Meier survival curves evaluated overall survival outcomes among Veterans.

resultsThe Veteran population was primarily white (78%), male (93%), and between 60 and 64 years old (18%). Individuals with a primary brain tumor in the general US population were mainly female (59%) and between 18 and 49 years old (28%). The overall AAIR of primary brain tumors from 2004 to 2018 within the Veterans Affairs cancer registry was 11.6. Nonmalignant tumors were more common than malignant tumors (AAIR:7.19 vs 4.42). The most diagnosed tumors in Veterans were nonmalignant pituitary tumors (AAIR:2.96), nonmalignant meningioma (AAIR:2.62), and glioblastoma (AAIR:1.96). In the Veteran population, survival outcomes became worse with age and were lowest among individuals diagnosed with glioblastoma.

conclusionsDifferences between Veteran and US populations can be broadly attributed to demographic composition differences of these groups. Prior to this, there have been no reports on national-level incidence rates and survival outcomes for Veterans. These data provide vital information that can drive efforts to understand disease burden and improve outcomes for individuals with primary brain tumors.

Indexed as

Brain NeoplasmsGlioblastomaMeningeal NeoplasmsMeningiomaVeteransAdolescentAdultFemaleHumansMaleMiddle AgedUnited StatesYoung Adultbrain tumorsincidencesurvivalveterans

Identifiers

PMID37738677
PMCPMC10836768
OpenAlexW4386948083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.