Evidence map›Paper›PMID 37738538›Full record

ArticleJCO global oncology2023

Benchmarking of the Cervical Cancer Care Cascade and Survival Outcomes After Radiation Treatment in a Low- and Middle-Income Country Setting.

Surbhi Grover, Emily MacDuffie, Memory Nsingo, Xiudong Lei, Priyanka Mehta, Sonya Davey, Sandra Urusaro, Sebathu Chiyapo, Peter Vuylsteke, Barati Monare and 5 more

Open access · goldAbstract read
In one paragraph

Article in JCO global oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 2 countries.

Surbhi GroverDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-7443-5937
Emily MacDuffieDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-8479-8512
Memory NsingoDepartment of Oncology, Gaborone Private Hospital, Gaborone, Botswana.
Xiudong LeiDepartment of Health Services Research, MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-5346-2992
Priyanka MehtaDepartment of Gynecology & Obstetrics, Emory University, Atlanta, GA.ORCID 0000-0001-8280-2645
Sonya DaveyDepartment of Medicine, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0003-4907-9920
Sandra UrusaroBotswana-UPenn Partnership, Gaborone, Botswana.ORCID 0000-0001-6843-0662
Sebathu ChiyapoPrincess Marina Hospital, Gaborone, Botswana.ORCID 0000-0001-9800-1455
Peter VuylstekeDepartment of Medicine, University of Botswana, Gaborone, Botswana.ORCID 0000-0001-6401-3722
Barati MonareBotswana-UPenn Partnership, Gaborone, Botswana.
Lisa Bazzett-MatabelePrincess Marina Hospital, Gaborone, Botswana.ORCID 0000-0002-6170-1084
Tlotlo RalefalaPrincess Marina Hospital, Gaborone, Botswana.
Rebecca LuckettPrincess Marina Hospital, Gaborone, Botswana.ORCID 0000-0002-1975-8837
Doreen Ramogola-MasireDepartment of Obstetrics and Gynecology, University of Botswana, Gaborone, Botswana.ORCID 0000-0001-9624-8366
Grace L SmithDepartment of Health Services Research, MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-3171-2911
University of Botswana · BWBotswana Harvard AIDS Institute Partnership · BWThe University of Texas MD Anderson Cancer Center · USBeth Israel Deaconess Medical Center · USBotswana Open University · BWBrigham and Women's Hospital · USEmory University · USUniversity of Pennsylvania · USUniversity of Washington · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Shared Resources CoreU54CA190158 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROBERTSON, ERLE S. · 2014 to 2023
$4.2M
Prognostic value of quantitative HPV viral load in determining cervical cancer treatment response and recurrenceK08CA230170 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GROVER, SURBHI · 2019 to 2023
$1.4M
Evaluation of triage strategies and screening intervals in a human papillomavirus based cervical cancer screening program in women living with human immunodeficiency virus in BotswanaK08CA271949 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Rebecca Luckett · 2022 to 2026
$1.3M
Economic Strain and Resilience in Cancer Patients: Assessing Patient-Reported Measures of the Burdens of TreatmentK07CA211804 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SMITH, GRACE · 2016 to 2020
$853k
NCI NIH HHS K07 CA211804NCI NIH HHS K08 CA230170NCI NIH HHS K08 CA271949NCI NIH HHS P30 CA016672NCI NIH HHS U54 CA190158
6 · The paper itself

Abstract

purposeTimely radiation treatment (RT) is critical in cervical cancer treatment, but patients in low- and middle-income countries (LMICs) in sub-Saharan Africa often face barriers that delay care. Time to care was benchmarked in a multidisciplinary team (MDT) setting in Botswana.

methodsTime intervals between steps in care were recorded for 230 patients reviewed at MDT between January 2016 and July 2018. Associations between RT delay and overall survival (OS) were evaluated using Kaplan-Meier curves and multivariable Cox proportional hazards models.

resultsFor patients who received RT (n = 187; 81.3%), the median biopsy to pathology reporting interval was 25 (IQR, 19-36) days and was 57 (IQR, 28-68) days for patients who did not (

conclusionThe MDT-coordinated care model allows for systematic benchmarking of the patient treatment cascade. Barriers to timely treatment exist for this cohort in Botswana, and RT delay may be associated with OS of patients receiving curative treatment. Interventions to accelerate the timing of the radiation oncology care cascade may improve clinical outcomes in this LMIC setting.

Indexed as

Radiation OncologyUterine Cervical NeoplasmsBenchmarkingBiopsyBotswanaFemaleHumans

Identifiers

PMID37738538
PMCPMC10846778
OpenAlexW4386949988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.