Evidence map›Paper›PMID 37738307›Full record

SynthesisThe journals of gerontology. Series A, Biological sciences and medical sciences2024

Cardiovascular Disorders and Falls Among Older Adults: A Systematic Review and Meta-Analysis.

Robbie Bourke, Paul Doody, Sergio Pérez, David Moloney, Lewis A Lipsitz, Rose Anne Kenny

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. A Closed-Loop Cardiovascular Model of the Supine-To-Stand Manoeuvre: Implications for Falls.International journal for numerical methods in biomedical engineering · 2026
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  5. Review
  6. Agricultural Injuries With Dementia: Double Whammy?American journal of industrial medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Robbie BourkeDepartment of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Paul DoodyDepartment of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0001-6732-1384
Sergio PérezDepartment of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
David MoloneyDepartment of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Lewis A LipsitzBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Rose Anne KennyDepartment of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Trinity College Dublin · IEBeth Israel Deaconess Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFalls are a common cause of injury, hospitalization, functional decline, and residential care admission among older adults. Cardiovascular disorders are recognized risk factors for falls. This systematic review assesses the association between cardiovascular disorders and falls in older adults.

methodsSystematic searches were conducted on MEDLINE and Embase, encompassing all literature published prior to December 31, 2022. Included studies addressed persons aged 50 years and older, and assessed the association between cardiovascular disorders and falls or the efficacy of cardiovascular-based interventions to reduce falls. Two reviewers independently extracted data and assessed study quality utilizing a modified Newcastle-Ottawa scale for observational studies, and the Cochrane Risk of Bias 2 tool for interventional studies. A systematic narrative analysis of all cardiovascular outcomes, and meta-analyses of unadjusted odds ratios (ORs) were performed.

resultsOne hundred and eighty-four studies were included: 181 observational and 3 interventional. Several cardiovascular disorders, including stroke, coronary artery disease, valvular heart disease, arterial stiffness, arrhythmia, orthostatic hypotension, and carotid sinus hypersensitivity, were consistently associated with falls. In meta-analysis of unadjusted ORs, the largest positive pooled associations with falls during a 12-month reporting interval were for stroke (OR: 1.90, 95% confidence interval [CI]: 1.70-2.11), peripheral arterial disease (OR: 1.82, 95% CI: 1.12-2.95), atrial fibrillation (OR: 1.52, 95% CI: 1.27-1.82), and orthostatic hypotension (OR: 1.39, 95% CI: 1.18-1.64).

conclusionsSeveral cardiovascular disorders are associated with falls. These results suggest the need to incorporate cardiovascular assessments for patients with falls. This review informed the cardiovascular recommendations in the new World Guidelines for falls in older adults.Clinical Trials Registration Number: CRD42021272245.

Indexed as

Cardiovascular DiseasesHypotension, OrthostaticStrokeAccidental FallsAgedHumansMiddle AgedRisk FactorsCardiovascularCarotid sinus hypersensitivityHypertensionOrthostatic hypotensionSyncope

Identifiers

PMID37738307
PMCPMC10809055
OpenAlexW4386953687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.