ArticleACS nano2023
Topological Darkness: How to Design a Metamaterial for Optical Biosensing with Ultrahigh Sensitivity.
Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- VONanomaterials (Basel, Switzerland) · 2026Article
- Giant photorefractive and photoexpansion effects in a van der Waals semiconductor.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Extreme sensitivity label-free biosensing platform based on topologically disruptive phase nano-optics.Microsystems & nanoengineering · 2026Article
- The influence of shot noise on the performance of phase singularity-based refractometric sensors.Nanophotonics (Berlin, Germany) · 2025Article
- Article
- Surface Relief Gratings of Slide-Ring Hydrogels for Label-Free Biosensing.Gels (Basel, Switzerland) · 2025Article
- Graphene-Inspired Wafer-Scale Ultrathin Gold Films.Nano letters · 2024Article
- Exploiting Topological Darkness in Photonic Crystal Slabs for Spatiotemporal Vortex Generation.Nano letters · 2024Article
- Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials.Light, science & applications · 2024Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the absence of labels and fast analyses, optical biosensors promise major advances in biomedical diagnostics, security, environmental, and food safety applications. However, the sensitivity of the most advanced plasmonic biosensor implementations has a fundamental limitation caused by losses in the system and/or geometry of biochips. Here, we report a "scissor effect" in topologically dark metamaterials which is capable of providing ultrahigh-amplitude sensitivity to biosensing events, thus solving the bottleneck sensitivity limitation problem. We explain how the "scissor effect" can be realized via the proper design of topologically dark metamaterials and describe strategies for their fabrication. To validate the applicability of this effect in biosensing, we demonstrate the detection of folic acid (vitamin important for human health) in a wide 3-log linear dynamic range with a limit of detection of 0.22 nM, which is orders of magnitude better than those previously reported for all optical counterparts. Our work provides possibilities for designing and realizing plasmonic, semiconductor, and dielectric metamaterials with ultrasensitivity to binding events.
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