Evidence map›Paper›PMID 37737731›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Calcium handling dysfunction and cardiac damage following acute ventricular preload challenge in the dystrophin-deficient mouse heart.

Vivian Haffner, Zahra Nourian, Erika M Boerman, Michelle D Lambert, Laurin M Hanft, Maike Krenz, Christopher P Baines, Dongsheng Duan, Kerry S McDonald, Timothy L Domeier

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac NaAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  3. Article
  4. Empagliflozin treatment rescues abnormally reduced NaAmerican journal of physiology. Heart and circulatory physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Vivian HaffnerDepartment of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, United States.
Zahra NourianDepartment of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, United States.
Erika M BoermanDepartment of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0001-8103-3485
Michelle D LambertDepartment of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, United States.
Laurin M HanftDepartment of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, United States.
Maike KrenzDepartment of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, United States.
Christopher P BainesDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States.
Dongsheng DuanDepartment of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri, United States.
Kerry S McDonaldDepartment of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0002-1588-1782
Timothy L DomeierDepartment of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, United States.ORCID 0000-0003-0340-6551
University of Missouri · USMissouri College · US

Funding

Cardiomyocyte TRPV4 and cardiac dysfunction following ischemia-reperfusion in the aged heart.R01HL136292 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Timothy Lee Domeier · 2017 to 2026
$3.5M
Treatment of Duchenne Muscular Dystrophy with the Muscle Calcium PumpR01AR070517 · NIAMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI DUAN, DONGSHENG · 2016 to 2020
$3.1M
NHLBI NIH HHS R01 HL136292NIAMS NIH HHS R01 AR070517
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy and is caused by mutations in the dystrophin gene. Dystrophin deficiency is associated with structural and functional changes of the muscle cell sarcolemma and/or stretch-induced ion channel activation. In this investigation, we use mice with transgenic cardiomyocyte-specific expression of the GCaMP6f Ca

Indexed as

DystrophinMuscular Dystrophy, DuchenneAnimalsArrhythmias, CardiacCalciumDisease Models, AnimalDisease ProgressionMaleMiceMice, Inbred mdxMice, TransgenicMyocytes, CardiacCalciumDystrophincalcium overloadcardiomyopathyDuchennemuscular dystrophystretch

Identifiers

PMID37737731
PMCPMC10907071
OpenAlexW4386945565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.