Evidence map›Paper›PMID 37737624›Full record

ArticleMicrobiology spectrum2023

Alternative molecular and genomic strategies to provide a rapid response to alerts concerning the introduction of new emerging SARS-CoV-2 variants: the Omicron alert.

Marta Herranz, Sergio Buenestado-Serrano, Javier Martín-Escolano, Andrea Molero-Salinas, Roberto Alonso, Pilar Catalán, Patricia Muñoz, Darío García de Viedma, Laura Pérez-Lago, Gregorio Marañón Microbiology-ID COVID 19 Study Group

Abstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marta HerranzServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.
Sergio Buenestado-SerranoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.ORCID 0000-0003-1739-4459
Javier Martín-EscolanoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.
Andrea Molero-SalinasServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.
Roberto AlonsoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.ORCID 0000-0002-0516-6371
Pilar CatalánServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.
Patricia MuñozServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.ORCID 0000-0001-5706-5583
Darío García de ViedmaServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.
Laura Pérez-LagoServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.ORCID 0000-0001-5249-7619
Gregorio Marañón Microbiology-ID COVID 19 Study GroupServicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital , Madrid, Spain.

Funding

CIBER-Consorcio Centro de Investigación Biomédica en Red CB06/06/0058EC | European Regional Development Fund (ERDF)Instituto de Investigación sanitaria Gregorio Marañón 2011-II-PI-01MEC | Instituto de Salud Carlos III (ISCIII) CPII20/00001MEC | Instituto de Salud Carlos III (ISCIII) FI22/00145MEC | Instituto de Salud Carlos III (ISCIII) PI21/01823
6 · The paper itself

Abstract

importanceThe study presents different experimental alternatives to identify new variants of concern (VOCs) of SARS-CoV-2 entering a certain population. Early detection of a new VOC is crucial for surveillance and control of spread. The objective is to provide laboratories with tools adapted to their resource capabilities that offer a sufficient level of resolution to rule out, confirm, or pre-assign the presence of a suspected VOC. The study describes four different techniques that were applied simultaneously to the first suspected Omicron case in Spain, highlighting the level of resolution and response time achieved in each case. These techniques are based on the detection of mutations in the S-gene of the virus that can easily adapt to potential emerging variants. The results of the study allow any laboratory to prepare for new alerts of SARS-CoV-2 VOCs.

Indexed as

genomic strategiesmolecular toolsOmicronSARS-CoV-2VOC alert

Identifiers

PMID37737624
PMCPMC10586716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.