Evidence map›Paper›PMID 37737614›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming.

Chima V Maduka, Mohammed Alhaj, Evran Ural, Oluwatosin M Habeeb, Maxwell M Kuhnert, Kylie Smith, Ashley V Makela, Hunter Pope, Shoue Chen, Jeremy M Hix and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Chima V MadukaComparative Medicine & Integrative Biology, Michigan State University, East Lansing, MI, 48824, USA.ORCID 0000-0002-3290-8852
Mohammed AlhajDepartment of Chemical Engineering & Materials Science, Michigan State University, East Lansing, MI, 48824, USA.
Evran UralDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Oluwatosin M HabeebDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Maxwell M KuhnertDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Kylie SmithDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Ashley V MakelaDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Hunter PopeDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Shoue ChenSchool of Packaging, Michigan State University, East Lansing, MI, 48824, USA.
Jeremy M HixInstitute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Christiane L MallettInstitute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Seock-Jin ChungDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Maxwell HakunDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Anthony TundoDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Kurt R ZinnDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Kurt D HankensonDepartment of Orthopedic Surgery, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Stuart B GoodmanDepartment of Orthopedic Surgery, Stanford University, Stanford, CA, 94063, USA.
Ramani NarayanDepartment of Chemical Engineering & Materials Science, Michigan State University, East Lansing, MI, 48824, USA.
Christopher H ContagDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Michigan State University · USStanford Medicine · USUniversity of Michigan · US

Funding

James and Kathleen Cornelius Endowment at Michigan State University
6 · The paper itself

Abstract

Polylactide (PLA) is the most widely utilized biopolymer in medicine. However, chronic inflammation and excessive fibrosis resulting from its degradation remain significant obstacles to extended clinical use. Immune cell activation has been correlated to the acidity of breakdown products, yet methods to neutralize the pH have not significantly reduced adverse responses. Using a bioenergetic model, delayed cellular changes were observed that are not apparent in the short-term. Amorphous and semi-crystalline PLA degradation products, including monomeric l-lactic acid, mechanistically remodel metabolism in cells leading to a reactive immune microenvironment characterized by elevated proinflammatory cytokines. Selective inhibition of metabolic reprogramming and altered bioenergetics both reduce these undesirable high cytokine levels and stimulate anti-inflammatory signals. The results present a new biocompatibility paradigm by identifying metabolism as a target for immunomodulation to increase tolerance to biomaterials, ensuring safe clinical application of PLA-based implants for soft- and hard-tissue regeneration, and advancing nanomedicine and drug delivery.

Indexed as

InflammationPolyestersBiocompatible MaterialsCytokinesHumansBiocompatible MaterialsCytokinesPolyesterspoly(lactide)biocompatibilityimmune cellsmetabolic reprogrammingpolylactidetissue regeneration

Identifiers

PMID37737614
PMCPMC10625072
OpenAlexW4386945477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.