Evidence map›Paper›PMID 37737591›Full record

ArticlemBio2023

Host subversion of bacterial metallophore usage drives copper intoxication.

Saika Hossain, Jacqueline R Morey, Stephanie L Neville, Katherine Ganio, Jana N Radin, Javiera Norambuena, Jeff M Boyd, Christopher A McDevitt, Thomas E Kehl-Fie

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Pseudogenization of the cntQ permease confers distinct yersinopine-metal uptake selectivity in Yersinia species.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Zinc acquisition and its contribution toFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Saika HossainDepartment of Microbiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.
Jacqueline R MoreyDepartment of Microbiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.
Stephanie L NevilleDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria, Australia.
Katherine GanioDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria, Australia.
Jana N RadinDepartment of Microbiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.
Javiera NorambuenaDepartment of Biochemistry and Microbiology, Rutgers University , New Brunswick, New Jersey, USA.
Jeff M BoydDepartment of Biochemistry and Microbiology, Rutgers University , New Brunswick, New Jersey, USA.
Christopher A McDevittDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria, Australia.
Thomas E Kehl-FieDepartment of Microbiology, University of Illinois at Urbana-Champaign , Urbana, Illinois, USA.ORCID 0000-0001-8234-1113
University of Illinois Urbana-Champaign · USThe University of Melbourne · AURutgers, The State University of New Jersey · US

Funding

Leveraging host-imposed metal starvation to elucidate the molecular and environmental factors that dictate metal utilization by the iron/manganese superoxide dismutase superfamilyR01AI155611 · NIAID · UNIVERSITY OF IOWA · PI KEHL-FIE, THOMAS EVERETT · 2021 to 2025
$2.8M
Mechanisms of cellular respiration-dependent cell lysis and its impact on biofilm formation and disassembly in Staphylococcus aureus.R01AI139100 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI BOYD, JEFF M · 2018 to 2022
$1.9M
Overcoming nutritional immunity: Staphylococcal adaptation to host-imposed manganese and zinc starvationR01AI118880 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KEHL-FIE, THOMAS EVERETT · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI118880NIAID NIH HHS R01 AI139100NIAID NIH HHS R01 AI155611
6 · The paper itself

Abstract

importanceDuring infection, bacteria must overcome the dual threats of metal starvation and intoxication. This work reveals that the zinc-withholding response of the host sensitizes

Indexed as

CopperStaphylococcus aureusBacteriaMetalsZincCopperMetalsZinccopperintoxicationnutrient transportnutritional immunityStaphylococcus aureusstaphylopinestarvationzinc

Identifiers

PMID37737591
PMCPMC10653882
OpenAlexW4386944770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.