Evidence map›Paper›PMID 37737438›Full record

ArticleSpine deformity2024

Quantifying a novel three-dimensional marker of scoliosis.

Toren Arginteanu, Ryan S Gallagher, Austin J Borja, Gregory Glauser, Lachlan J Smith, Saba Pasha, Dennis DeTurck, Neil R Malhotra

Abstract read
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In one paragraph

Article in Spine deformity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Toren ArginteanuDepartment of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, 3rd Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Ryan S GallagherDepartment of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, 3rd Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Austin J BorjaDepartment of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, 3rd Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Gregory GlauserDepartment of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, 3rd Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Lachlan J SmithDepartment of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, 3rd Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Saba PashaDivision of Orthopaedic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Dennis DeTurckDepartment of Mathematics, David Rittenhouse Lab, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Neil R MalhotraDepartment of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, 3rd Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, PA, 19104, USA. neil.malhotra@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-0754-6423
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundScoliosis causes abnormal spinal curvature and torsional rotation of the vertebrae and has implications for human suffering and societal cost. In differential geometry, Writhe describes three-dimensional curvature. Differential geometric quantities can inform better diagnostic metrics of scoliotic deformity. This evaluation could help physicians and researchers study scoliosis and determine treatments.

methodsEight adult lumbar spine CT scans were analyzed in custom MATLAB programs to estimate Writhe and Cobb angle. Five patients exhibited scoliotic curvature, and three controls were asymptomatic. Vertebral centroids in three-dimensional space were determined, and Writhe was approximated. A T-test determined whether the affected spines had greater Writhe than the controls. Cohen's D test was used to determine effect size.

resultsWrithe of scoliotic spines (5.4E-4 ± 2.7E-4) was significantly higher than non-scoliotic spines (8.2E-5 ± 1.1E-4; p = 0.008).

conclusionWrithe, a measure of curvature derived from 3D imaging, is significantly greater in scoliotic than in non-scoliotic spines. Future directions must include more subjects and examine writhe as a marker of scoliosis severity, progression, and response to treatment.

Indexed as

ScoliosisAdultForecastingHumansImaging, Three-DimensionalSpineBiomechanicsDifferential geometryScoliosisSpine

Identifiers

PMID37737438
OpenAlexW4386944578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.