Evidence map›Paper›PMID 37737273›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024

Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness.

Julian Wenzel, Luzie Badde, Shalaila S Haas, Carolina Bonivento, Tamsyn E Van Rheenen, Linda A Antonucci, Anne Ruef, Nora Penzel, Marlene Rosen, Theresa Lichtenstein and 19 more

Open access · hybridAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 7 countries.

Julian Wenzel *Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. julian.wenzel@uk-koeln.de.ORCID http://orcid.org/0000-0002-3657-4263
Luzie Badde *Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Shalaila S HaasDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, NY, USA.ORCID http://orcid.org/0000-0003-1385-1050
Carolina BoniventoScientific Institute, IRCCS E, Medea, Pasian di Prato, Udine, Italy.ORCID http://orcid.org/0000-0003-3354-7494
Tamsyn E Van RheenenCentre for Mental Health, School of Health Sciences, Swinburne University of Technology, Melbourne, VIC, Australia.
Linda A AntonucciDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Munich, Germany.
Anne RuefDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Munich, Germany.
Nora PenzelDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0003-1624-386X
Marlene RosenDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Theresa LichtensteinDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Paris Alexandros LalousisInstitute of Psychiatry, Psychology & Neuroscience, Department of Psychosis Studies, King's College London, London, UK.
Marco PaoliniDepartment of Radiology, University Hospital, Ludwig-Maximilian University, Munich, Germany.
Alexandra StaintonOrygen, Melbourne, VIC, Australia.
Udo DannlowskiInstitute for Translational Psychiatry, University of Muenster, Münster, Germany.ORCID http://orcid.org/0000-0002-0623-3759
Georg RomerDepartment of Child and Adolescent Psychiatry, University of Münster, Münster, Germany.
Paolo BrambillaDepartment of Neuosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0002-4021-8456
Stephen J WoodOrygen, Melbourne, VIC, Australia.
Rachel UpthegroveSchool of Psychology, University of Birmingham, Birmingham, UK.
Stefan BorgwardtTranslational Psychiatry Unit (TPU), Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany.ORCID http://orcid.org/0000-0002-5792-3987
Eva MeisenzahlDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Raimo K R SalokangasDepartment of Psychiatry, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-8532-1596
Christos PantelisMelbourne Neuropsychiatry Centre, University of Melbourne & Western Health, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-9565-0238
Rebekka LencerInstitute for Translational Psychiatry, University of Muenster, Münster, Germany.ORCID http://orcid.org/0000-0003-4032-7297
Alessandro BertolinoDepartment of Translational Biomedicine and Neuroscience - University of Bari Aldo Moro, Bari, Italy.
Joseph KambeitzDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-8988-3959
Nikolaos KoutsoulerisDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Munich, Germany.ORCID http://orcid.org/0000-0001-6825-6262
Dominic B DwyerDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Munich, Germany.ORCID http://orcid.org/0000-0003-3949-5867
Lana Kambeitz-IlankovicDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
PRONIA consortium
University of Turku · FILudwig-Maximilians-Universität München · DEUniversity of Cologne · DEUniversity of Basel · CHUniversity of Bari Aldo Moro · ITInstitute of Mental Health · GBUniversity of Milan · ITHeinrich Heine University Düsseldorf · DEUniversity of Münster · DEOspedale San Paolo · ITUniversity of Udine · ITThe University of Melbourne · AUAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITGeneral Electric (Germany) · DEIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USKing's College London · GBUniversity of Foggia · ITIRCCS Eugenio Medea · ITLibera Università Maria SS. Assunta · IT

Funding

Training the next generation of clinical neuroscientistsT32MH122394 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rene S. Kahn, ANTONIA S NEW · 2020 to 2026
$2.5M
NIMH NIH HHS T32 MH122394
6 · The paper itself

Abstract

Cognitively impaired and spared patient subgroups were identified in psychosis and depression, and in clinical high-risk for psychosis (CHR). Studies suggest differences in underlying brain structural and functional characteristics. It is unclear whether cognitive subgroups are transdiagnostic phenomena in early stages of psychotic and affective disorder which can be validated on the neural level. Patients with recent-onset psychosis (ROP; N = 140; female = 54), recent-onset depression (ROD; N = 130; female = 73), CHR (N = 128; female = 61) and healthy controls (HC; N = 270; female = 165) were recruited through the multi-site study PRONIA. The transdiagnostic sample and individual study groups were clustered into subgroups based on their performance in eight cognitive domains and characterized by gray matter volume (sMRI) and resting-state functional connectivity (rsFC) using support vector machine (SVM) classification. We identified an impaired subgroup (N

Indexed as

Cognitive DysfunctionPsychotic DisordersBrainExecutive FunctionFemaleGray MatterHumansMaleMulticenter Studies as Topic

Identifiers

PMID37737273
PMCPMC10789737
OpenAlexW4386945514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.