ArticleNature communications2023
Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Biosynthesis of Phosphatidylethanolamine and Phosphatidylcholine via the Kennedy Pathway in Cancer and Other Pathological Conditions.International journal of molecular sciences · 2026Review
- The Genetic Landscape of Androgenetic Alopecia: Current Knowledge and Future Perspectives.Biology · 2026Review
- The Roles of EDA2R in Ageing and Disease.Aging cell · 2025Review
- Androgenetic alopecia.Nature reviews. Disease primers · 2025Review
- Application of multi-omics techniques to androgenetic alopecia: Current status and perspectives.Computational and structural biotechnology journal · 2024Review
- Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment.Pharmaceutics · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Male-pattern hair loss (MPHL) is common and highly heritable. While genome-wide association studies (GWAS) have generated insights into the contribution of common variants to MPHL etiology, the relevance of rare variants remains unclear. To determine the contribution of rare variants to MPHL etiology, we perform gene-based and single-variant analyses in exome-sequencing data from 72,469 male UK Biobank participants. While our population-level risk prediction suggests that rare variants make only a minor contribution to general MPHL risk, our rare variant collapsing tests identified a total of five significant gene associations. These findings provide additional evidence for previously implicated genes (EDA2R, WNT10A) and highlight novel risk genes at and beyond GWAS loci (HEPH, CEPT1, EIF3F). Furthermore, MPHL-associated genes are enriched for genes considered causal for monogenic trichoses. Together, our findings broaden the MPHL-associated allelic spectrum and provide insights into MPHL pathobiology and a shared basis with monogenic hair loss disorders.
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Registered trials
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