Evidence map›Paper›PMID 37737171›Full record

ArticleRespiratory research2023

Incident low muscle mass is associated with greater lung disease and lower circulating leptin in a tobacco-exposed longitudinal cohort.

Richard H Zou, S Mehdi Nouraie, Chad Karoleski, Yingze Zhang, Frank C Sciurba, Daniel E Forman, Jessica Bon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
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  6. Article
  7. COPD and Metabolic Syndrome: Unanswered Questions and Opportunities for Innovation.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Richard H ZouDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
S Mehdi NouraieDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Chad KaroleskiEmphysema COPD Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
Yingze ZhangDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Frank C SciurbaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Daniel E FormanDivision of Cardiology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Jessica BonDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. bonjm@upmc.edu.
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · USVA Pittsburgh Healthcare System · US

Funding

Peripheral Markers of Phenotypic Heterogeneity in COPDP50HL084948 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHOI, AUGUSTINE M · 2007 to 2012
$12.8M
Phenotypes of Muscle Loss in SmokersF32HL164309 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZOU, RICHARD HANG · 2022 to 2022
$79k
NHLBI NIH HHS F32 HL164309NHLBI NIH HHS P50 HL084948NIH HHS F32 HL164309NIH HHS P50 HL084948NIH HHS R01 HL12828901
6 · The paper itself

Abstract

backgroundMuscle loss is prevalent in chronic obstructive pulmonary disease (COPD). Prior studies evaluating musculoskeletal dysfunction in COPD have focused on individuals with baseline low muscle mass. Currently, there is limited data evaluating clinical characteristics and outcomes associated with progression to incident low muscle mass in a tobacco-exposed cohort of individuals with baseline normal muscle mass.

methodsWe evaluated 246 participants from a single-center longitudinal tobacco-exposed cohort with serial spirometry, thoracic imaging, dual energy x-ray absorptiometry (DXA) measurements, walk testing, and plasma adipokine measurements. DXA-derived fat free mass index (FFMI) and appendicular skeletal mass index (ASMI) were used as surrogates for muscle mass. Participants with incident low muscle mass (LM) at follow-up were characterized by FFMI < 18.4 kg/m

resultsTwenty-five (10%) participants progressed to incident low muscle mass at follow-up. At baseline, the LM subgroup had greater active smoking prevalence (60% v. 38%, p = 0.04), lower FFMI (17.8 ± 1.7 kg/m

conclusionsWe identified a subgroup of tobacco-exposed individuals with normal baseline muscle mass who progressed to incident DXA-derived low muscle mass. This subgroup demonstrated synchronous lung disease and persistently low circulating leptin levels. Our study suggests the importance of assessing for muscle loss in conjunction with lung function decline when evaluating individuals with tobacco exposure.

Indexed as

Pulmonary Disease, Chronic ObstructiveFemaleHumansLeptinMaleMusclesSmokingLeptinAdipokinesChronic obstructivePulmonary diseaseSarcopenia

Identifiers

PMID37737171
PMCPMC10515430
OpenAlexW4386945211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.