Evidence map›Paper›PMID 37737093›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

A lone spike in blood glucose can enhance the thrombo-inflammatory response in cortical venules.

Iftach Shaked, Conrad Foo, Philipp Mächler, Rui Liu, Yingying Cui, Xiang Ji, Thomas Broggini, Tomasz Kaminski, Suchita Suryakant Jadhav, Prithu Sundd and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Iftach ShakedDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.
Conrad FooDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.
Philipp MächlerDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.
Rui LiuDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.
Yingying CuiDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.
Xiang JiDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.
Thomas BrogginiDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.
Tomasz KaminskiVascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Suchita Suryakant JadhavThe Adelson Medical School, Ariel University, Ariel, Israel.
Prithu SunddVascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Michael FirerThe Adelson Medical School, Ariel University, Ariel, Israel.
Anna DevorDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Beth FriedmanDepartment of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA.
David KleinfeldDepartment of Physics, University of California at San Diego, La Jolla, CA, USA.
University of California, San Diego · USAriel University · ILUniversity of Pittsburgh · USBoston University · US

Funding

Project 4U19NS123717 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LINNINGER, ANDREAS A · 2021 to 2025
$13.4M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Resilient versus fragile aspects of blood flow in the mammalian brainR35NS097265 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2017 to 2024
$6.8M
Pulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest SyndromeR01HL128297 · NHLBI · VERSITI WISCONSIN, INC. · PI SUNDD, PRITHU · 2015 to 2025
$5.4M
The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneityR01NS108472 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A, SCHAFFER, CHRIS B · 2018 to 2022
$3.2M
Mechanisms of platelet exosome-mediated acute chest syndrome in sickle cell diseaseR01HL141080 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D, NOVELLI, ENRICO M · 2019 to 2022
$3.1M
CD39-carrying extracellular vesicles regulate pulmonary thrombosis in Sickle Cell DiseaseR01HL166345 · NHLBI · VERSITI WISCONSIN, INC. · PI Prithu Sundd · 2023 to 2026
$3.1M
Imaging the molecular constituents of the brain vasculature and lymphatic connectomeU24EB028942 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2019 to 2024
$1.8M
NHLBI NIH HHS R01 HL128297NHLBI NIH HHS R01 HL141080NHLBI NIH HHS R01 HL166345NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS108472NINDS NIH HHS R35 NS097265NINDS NIH HHS U19 NS123717
6 · The paper itself

Abstract

How transient hyperglycemia contributes to cerebro-vascular disease has been a challenge to study under controlled physiological conditions. We use amplified, ultrashort laser-pulses to physically disrupt brain-venule endothelium at targeted locations. This vessel disruption is performed in conjunction with transient hyperglycemia from a single injection of metabolically active

Indexed as

Blood GlucoseGlucoseHyperglycemiaAnimalsBlood PlateletsEndothelium, VascularInflammationMiceNeutrophilsVenulesBlood GlucoseGlucoseGlucose, (L)-IsomerImagingneutrophilsplateletsreactive oxygen speciestransient hyperglycemia

Identifiers

PMID37737093
PMCPMC10993879
OpenAlexW4386945456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.