Evidence map›Paper›PMID 37736980›Full record

ArticleTomography (Ann Arbor, Mich.)2023

Atlas-Based Adaptive Hadamard-Encoded MR Spectroscopic Imaging at 3T.

Huawei Liu, Adam W Autry, Peder E Z Larson, Duan Xu, Yan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Huawei LiuDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107, USA.
Adam W AutryDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107, USA.ORCID 0000-0003-4183-3634
Duan XuDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107, USA.
Yan LiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107, USA.ORCID 0000-0003-2145-2869

Funding

Multimodality Neuroimaging Evaluation of Cognitive Functioning in Lower Grade AstrocytomaR01CA273028 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORDON, JEREMY WILLIAM, LI, YAN · 2022 to 2025
$3.3M
Quantitative Steady-State and Dynamic Metabolic MRI for Evaluating Patients with GliomaR01CA262630 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang, Albert Chen · 2022 to 2026
$3.3M
Simultaneous multi-slice GABA-edited MRSI in the developing brainR21HD092660 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, YAN · 2017 to 2018
$436k
NCI NIH HHS R01 CA262630NCI NIH HHS R01 CA273028NICHD NIH HHS R21 HD092660NIH HHS R01 CA262630NIH HHS R01 CA273028
6 · The paper itself

Abstract

backgroundThis study aimed to develop a time-efficient method of acquiring simultaneous, dual-slice MR spectroscopic imaging (MRSI) for the evaluation of brain metabolism.

methodsAdaptive Hadamard-encoded pulses were developed and integrated with atlas-based automatic prescription. The excitation profiles were evaluated via simulation, phantom and volunteer experiments. The feasibility of γ-aminobutyric acid (GABA)-edited dual-slice MRSI was also assessed.

resultsThe signal between slices in the dual-band MRSI was less than 1% of the slice profiles. Data from a homemade phantom containing separate, interfacing compartments of creatine and acetate solutions demonstrated ~0.4% acetate signal contamination relative to the amplitude in the excited creatine compartment. The normalized signal-to-noise ratios from atlas-based acquisitions in volunteers were found to be comparable between dual-slice, Hadamard-encoded MRSI and 3D acquisitions. The mean and standard deviation of the coefficients of variation for NAA/Cho from the repeated volunteer scans were 8.2% ± 0.8% and 10.1% ± 3.7% in the top and bottom slices, respectively. GABA-edited, dual-slice MRSI demonstrated simultaneous detection of signals from GABA and coedited macromolecules (GABA+) from both superior grey and deep grey regions of volunteers.

conclusionThis study demonstrated a fully automated dual-slice MRSI acquisition using atlas-based automatic prescription and adaptive Hadamard-encoded pulses.

Indexed as

CreatineMagnetic Resonance Imaginggamma-Aminobutyric AcidHumansPhantoms, ImagingSpectrum AnalysisCreatinegamma-Aminobutyric Acidautomatic prescriptiondual-sliceGABAHadamard pulsesMR spectroscopy

Identifiers

PMID37736980
PMCPMC10514830

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.