Evidence map›Paper›PMID 37736841›Full record

ArticleAnalytical and bioanalytical chemistry2023

Enhanced selective capture of phosphomonoester lipids enabling highly sensitive detection of sphingosine 1-phosphate.

Giuliana Grasso, Eduardo M Sommella, Fabrizio Merciai, Rahma Abouhany, Sudhirkumar A Shinde, Pietro Campiglia, Börje Sellergren, Carlo Crescenzi

Open access · hybridAbstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Giuliana GrassoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Eduardo M SommellaDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Fabrizio MerciaiDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Rahma AbouhanyBiofilm Research Center for Biointerfaces, Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, 23014, Malmö, Sweden.
Sudhirkumar A ShindeBiofilm Research Center for Biointerfaces, Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, 23014, Malmö, Sweden.
Pietro CampigliaDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Börje SellergrenBiofilm Research Center for Biointerfaces, Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, 23014, Malmö, Sweden.
Carlo CrescenziDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy. carlo.crescenzi@unisa.it.ORCID http://orcid.org/0000-0001-6950-1506
University of Salerno · ITMalmö University · SE

Funding

Università degli Studi di Salerno FARB 2018 "Simplifying lipid analysis with tailo
6 · The paper itself

Abstract

Sphingolipids play crucial roles in cellular membranes, myelin stability, and signalling responses to physiological cues and stress. Among them, sphingosine 1-phosphate (S1P) has been recognized as a relevant biomarker for neurodegenerative diseases, and its analogue FTY-720 has been approved by the FDA for the treatment of relapsing-remitting multiple sclerosis. Focusing on these targets, we here report three novel polymeric capture phases for the selective extraction of the natural biomarker and its analogue drug. To enhance analytical performance, we employed different synthetic approaches using a cationic monomer and a hydrophobic copolymer of styrene-DVB. Results have demonstrated high affinity of the sorbents towards S1P and fingolimod phosphate (FTY-720-P, FP). This evidence proved that lipids containing phosphate diester moiety in their structures did not constitute obstacles for the interaction of phosphate monoester lipids when loaded into an SPE cartridge. Our suggested approach offers a valuable tool for developing efficient analytical procedures.

Indexed as

LipidsLysophospholipidsSolid Phase ExtractionSphingosineHumansHydrophobic and Hydrophilic InteractionsLimit of DetectionOrganophosphatesPropylene GlycolsFTY 720PLipidsLysophospholipidsOrganophosphatesPropylene GlycolsSphingosinesphingosine 1-phosphateBioanalytical methodsBiological samplesBiopolymers/lipidsClinical/biomedical analysisPharmaceuticalsPolymers

Identifiers

PMID37736841
PMCPMC10567913
OpenAlexW4386944638

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.