Evidence map›Paper›PMID 37736820›Full record

ArticleEndocrine2024

Abdominal adipose tissue distribution assessed by computed tomography and mortality in hospitalised patients with COVID-19: a retrospective longitudinal cohort study.

Sofia Battisti, Claudio Pedone, Flavia Tramontana, Nicola Napoli, Ghadeer Alhamar, Emanuele Russo, Vanni Agnoletti, Elisa Paolucci, Mario Galgani, Emanuela Giampalma and 2 more

Abstract read
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In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Sofia BattistiRadiology Department, AUSL Romagna M. Bufalini Hospital, Cesena, Italy.
Claudio PedoneDepartment of Medicine and Surgery, Research Unit of Geriatrics, Università Campus Bio-Medico di Roma, Rome, Italy.
Flavia TramontanaDepartment of Medicine and Surgery, Research Unit of Endocrinology & Diabetes, Università Campus Bio-Medico di Roma, Rome, Italy.
Nicola NapoliDepartment of Medicine and Surgery, Research Unit of Endocrinology & Diabetes, Università Campus Bio-Medico di Roma, Rome, Italy.
Ghadeer AlhamarDepartment of Medicine and Surgery, Research Unit of Endocrinology & Diabetes, Università Campus Bio-Medico di Roma, Rome, Italy.
Emanuele RussoAnesthesia and Intensive Care Unit, AUSL Romagna, M.Bufalini Hospital, Cesena, Italy.
Vanni AgnolettiAnesthesia and Intensive Care Unit, AUSL Romagna, M.Bufalini Hospital, Cesena, Italy.
Elisa PaolucciInternal Medicine Unit, AUSL Romagna, M.Bufalini Hospital, Cesena, Italy.
Mario GalganiDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy.
Emanuela GiampalmaRadiology Department, AUSL Romagna M. Bufalini Hospital, Cesena, Italy.
Annalisa Paviglianiti *Department of Medicine and Surgery, Research Unit of Endocrinology & Diabetes, Università Campus Bio-Medico di Roma, Rome, Italy.
Rocky Strollo *Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy. rocky.strollo@uniroma5.it.ORCID 0000-0001-8967-7613
Università Campus Bio-Medico · ITOspedale “M. Bufalini” di Cesena · ITInstitute for Experimental Endocrinology and Oncology · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITSan Raffaele University of Rome · IT

Funding

European Foundation for the Study of Diabetes Mentorship AwardEuropean Society for Clinical Nutrition and Metabolism ESPEN Research FellowshipMinistero della Salute GR-2018-12365982Ordine dei Medici Salerno Fellowship
6 · The paper itself

Abstract

backgroundVisceral adiposity has been associated with an increased risk of critical illness in COVID-19 patients. However, if it also associates to a poor survival is still not well established. The aim of the study was to assess the relationship between abdominal fat distribution and COVID-19 mortality.

methodsIn this six-month longitudinal cohort study, abdominal visceral (VAT) and subcutaneous adipose tissues (SAT) were measured by computed tomography in a cohort of 174 patients admitted to the emergency department with a diagnosis of COVID-19, during the first wave of pandemic. The primary exposure and outcome measures were VAT and SAT at hospital admission, and death at 30 and 180 days, respectively.

resultsOverall survival was not different according to VAT (p = 0.94), SAT (p = 0.32) and VAT/SAT ratio (p = 0.64). However, patients in the lowest SAT quartile (thickness ≤ 11.25 mm) had a significantly reduced survival compared to those with thicker SAT (77 vs. 94% at day 30; 74 vs. 91% at day 180, p = 0.01). Similarly, a thinner SAT was associated with lower survival in Intensive Care Unit (ICU) admitted patients, independently of sex or age (p = 0.02). The VAT/SAT ratio showed a non-linear increased risk of ICU admission, which plateaued out and tended for inversion at values greater than 1.9 (p = 0.001), although was not associated with increased mortality rate.

conclusionsIn our cohort, visceral adiposity did not increase mortality in patients with COVID-19, but low SAT may be associated with poor survival.

Indexed as

COVID-19Intra-Abdominal FatAbdominal FatCohort StudiesHumansLongitudinal StudiesObesity, AbdominalRetrospective StudiesSubcutaneous FatTomography, X-Ray ComputedAdipose tissueComputed tomographyCOVID-19Fat distributionMortality.

Identifiers

PMID37736820
OpenAlexW4386945587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.