ArticleInternational journal of obesity (2005)2024
Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children.
Article in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children.Pediatric obesity · 2025Trial
- Composite Summary Scores Capture Obesogenic Eating Risk Among Preadolescents Using the Child Eating Behaviour Questionnaire.Pediatric obesity · 2026Article
- Validating a Short Version of the External Food Cue Responsiveness Scale (EFCR-6) in Preadolescents: Initial Evidence on Validity and Reliability.Research square · 2025Article
- Food switching at a meal is positively associated with change in adiposity among children at high-familial risk for obesity.Appetite · 2025Article
- A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature.Genome medicine · 2025Article
- The Effect of Parental Weight and Genetics on the Body Mass Index of Very Low Birth Weight Infants as They Reach School Age.Deutsches Arzteblatt international · 2025Observational
- Association between the Taq1A polymorphism and problematic media use in preadolescent children.Frontiers in psychology · 2024Article
- Genetic associations with neural reward responsivity to food cues in children.Frontiers in nutrition · 2024Article
- Child eating behavior predicts body mass index after 1 year: results from the Swiss Preschooler's Health Study (SPLASHY).Frontiers in psychology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectivesObesity polygenic risk scores (PRS) explain substantial variation in body mass index (BMI), yet associations between PRSs and appetitive traits in children remain unclear. To better understand pathways leading to pediatric obesity, this study aimed to assess the association of obesity PRSs and appetitive traits. SUBJECTS/
methodsThis study included 248 unrelated children aged 9-12 years. DNA from the children was genotyped (236 met quality control thresholds) and four weighted polygenic risk scores from previous studies were computed and standardized: a 97 SNP PRS, 266 SNP pediatric-specific PRS, 466 SNP adult-specific PRS, and ~2 million SNP PRS. Appetitive traits were assessed using a parent-completed Child Eating Behavior Questionnaire, which evaluated food approach/avoidance traits and a composite obesogenic appetite score. BMI was directly measured and standardized by age and sex. Three associations were evaluated with linear regression: (1) appetitive traits and BMI, (2) PRSs and BMI, and (3) PRSs and appetitive traits, the primary association of interest.
resultsExpected positive associations were observed between obesogenic appetitive traits and BMI and all four PRSs and BMI. Examining the association between PRSs and appetitive traits, all PRSs except for the 466 SNP adult PRS were significantly associated with the obesogenic appetite score. Each standard deviation increase in the 266 SNP pediatric PRS was associated with an adjusted 2.1% increase in obesogenic appetite score (95% CI: 0.6%, 3.7%, p = 0.006). Significant partial mediation of the PRS-BMI association by obesogenic appetite score was found for these PRSs; for example, 21.3% of the association between the 266 SNP pediatric PRS and BMI was explained by the obesogenic appetite score.
conclusionsGenetic obesity risk significantly predicted appetitive traits, which partially mediated the association between genetic obesity risk and BMI in children. These findings build a clearer picture of pathways leading to pediatric obesity.
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