Evidence map›Paper›PMID 37736773›Full record

ArticleJournal of cancer survivorship : research and practice2025

Auditory complications among childhood cancer survivors and health-related quality of life: a PanCareLIFE study.

Sven Strebel, Katja Baust, Desiree Grabow, Julianne Byrne, Thorsten Langer, Antoinette Am Zehnhoff-Dinnesen, Rahel Kuonen, Annette Weiss, Tomas Kepak, Jarmila Kruseova and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Cohort Profile Update: The Swiss Childhood Cancer Survivor Cohort.International journal of epidemiology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Approaches to Reduce Toxicity in Pediatric Brain Tumors.Current oncology (Toronto, Ont.) · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sven Strebel *Institute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Katja Baust *Department of Pediatric Hematology and Oncology, University Hospital Bonn, Bonn, Germany.
Desiree GrabowDivision of Childhood Cancer Epidemiology, German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Julianne ByrneBoyne Research Institute, Drogheda, Ireland.
Thorsten LangerDepartment of Pediatric Oncology and Hematology, University Hospital for Children and Adolescents, Lübeck, Germany.
Antoinette Am Zehnhoff-DinnesenDepartment for Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhems University, Münster, Germany.
Rahel KuonenInstitute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Annette WeissInstitute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Tomas KepakUniversity Hospital Brno & International Clinical Research Center (FNUSA-ICRC), Masaryk University, Brno, Czech Republic.
Jarmila KruseovaDepartment of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Claire BergerDepartment of Pediatric Hematology and Oncology, University-Hospital, Saint-Étienne, France.
Gabriele CalaminusDepartment of Pediatric Hematology and Oncology, University Hospital Bonn, Bonn, Germany.
Grit Sommer *Institute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland.
Claudia E Kuehni *Institute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland. claudia.kuehni@unibe.ch.
PanCareLIFE Consortium

Funding

European Union's Seventh Framework Program 602030German Cancer Aid 110298Krebsliga Schweiz KLS-3412-02-2014Swiss Cancer Research Foundation KFS-4157-02-2017University Hospital of Brno from the Ministry of Education, Youth and Sports of the Czech Republic 7E13061
6 · The paper itself

Abstract

purposeAuditory complications are potential side effects from childhood cancer treatment. Yet, limited evidence exists about the impact of auditory complications-particularly tinnitus-on health-related quality of life (HRQoL) among childhood cancer survivors (CCS). We determined the prevalence of hearing loss and tinnitus in the European PanCareLIFE cohort of CCS and examined its effect on HRQoL.

methodsWe included CCS from four European countries who were diagnosed at age ≤ 18 years; survived ≥ 5 years; and aged 25-44 years at study. We assessed HRQoL (Short Form 36), hearing loss, and tinnitus using questionnaires. We used multivariable linear regression to examine associations between these two auditory complications and HRQoL adjusting for socio-demographic and clinical factors.

resultsOur study population consisted of 6,318 CCS (53% female; median age at cancer diagnosis 9 years interquartile range [IQR] 5-13 years) with median age at survey of 31 years (IQR 28-35 years). Prevalence was 7.5% (476/6,318; confidence interval [CI]: 6.9-8.2) for hearing loss and 7.6% (127/1,668; CI: 6.4-9.0) for tinnitus. CCS with hearing loss had impaired physical (coefficient [coef.] -4.3, CI: -7.0 to -1.6) and mental (coef. -3.2, CI: -5.5 to -0.8) HRQoL when compared with CCS with normal hearing. Tinnitus was associated with impaired physical (coef. -8.2, CI: -11.8 to -4.7) and mental (coef. -5.9, CI: -8.8 to -3.1) HRQoL.

conclusionWe observed reduced HRQoL among CCS with hearing loss and tinnitus. Our findings indicate timely treatment of hearing loss and tinnitus may contribute to quality of life of survivors. IMPLICATIONS FOR CANCER SURVIVORS: CCS who experience auditory complications should be counseled about possible therapeutic and supportive measures during follow-up care.

Indexed as

Cancer SurvivorsHearing LossNeoplasmsQuality of LifeTinnitusAdolescentAdultChildChild, PreschoolEuropeFemaleHumansMalePrevalenceSurveys and QuestionnairesYoung AdultChildhood cancerHearing lossQuality of lifeSurvivorshipTinnitus

Identifiers

PMID37736773
PMCPMC11813997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.