Evidence map›Paper›PMID 37736726›Full record

ArticleJournal of nanobiotechnology2023

Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis.

Shu Zhao, Guanghui Xiu, Jian Wang, Yi Wen, Jinyuan Lu, Baitong Wu, Guangming Wang, Danjing Yang, Bin Ling, Dajiang Du and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 3 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Shu ZhaoEast Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China, 200120.
Guanghui XiuDepartment of Intensive Care Unit, Affiliated Hospital of Yunnan University (The Second People's Hospital of Yunnan Province), Yunnan University, Kunming, 650021, People's Republic of China.
Jian WangEast Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China, 200120.
Yi WenEast Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China, 200120.
Jinyuan LuDepartment of Hematology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Baitong WuEast Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China, 200120.
Guangming WangEast Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China, 200120.
Danjing YangEast Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China, 200120.
Bin LingDepartment of Intensive Care Unit, Affiliated Hospital of Yunnan University (The Second People's Hospital of Yunnan Province), Yunnan University, Kunming, 650021, People's Republic of China. ynshhyyicu@163.com.
Dajiang DuInstitute of Microsurgery on Extremities, and Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People's Republic of China. dudajiang@sjtu.edu.cn.
Jun XuEast Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China, 200120. xunymc2000@yahoo.com.
Shanghai East Hospital · CNSecond People's Hospital of Yunnan Province · CNShanghai Jiao Tong University · CNTongji Hospital · CNYunnan University · CN

Funding

Innovation Program of Shanghai Municipal Education Commission 2023ZKZD31National Natural Science Foundation of China 31671055National Natural Science Foundation of China 32170986National Natural Science Foundation of China 81901950Natural Science Foundation of Shanghai 21ZR1448000the National Major Scientific and Technological Special Project for "Significant New Drugs Development" 2018ZX09201002-005the Xu Jun's expert work station 202005AF150050
6 · The paper itself

Abstract

Osteoarthritis (OA) is a degenerative joint disease involving cartilage. Exosomes derived from Mesenchymal stem cells (MSCs) therapy improves articular cartilage repair, but subcutaneous fat (SC) stromal cells derived exosomes (MSCs

Indexed as

ExosomesMesenchymal Stem CellsMicroRNAsOsteoarthritisAnimalsHumansMiceRatsSubcutaneous FatMicroRNAsAutophagyCartilage-targetedEngineering exosomesmiR-199a-3pOsteoarthritis

Identifiers

PMID37736726
PMCPMC10515007
OpenAlexW4386944090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.