ArticleEuropean journal of medical research2023
Influence of perioperative blood pressure regulation on postoperative delirium in patients undergoing head and neck free flap reconstruction.
Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06928870 (The Effect of Controlled Hypotension on Cerebral Oxygen Saturation in Spinal Surgery), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Controlled Hypotension on Cerebral Oxygen Saturation in Spinal Surgery
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Factors associated with postoperative delirium in patients undergoing oral and maxillofacial surgery: a meta-analysis of observational study.Frontiers in medicine · 2026Pooled it
- Relationship between duration of intraoperative hypotension and postoperative delirium in patients undergoing head and neck cancer surgery with free flap reconstruction: a retrospective observational study.Journal of anesthesia · 2026Observational
- Postoperative delirium in patients with free flap reconstruction after head and neck tumor surgery: influencing factors for severity and onset time, and a prediction model.BMC oral health · 2025Article
- Perioperative blood pressure variability as a risk factor for postoperative delirium in the patients receiving cardiac surgery.BMC anesthesiology · 2024Article
- Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique.World journal of gastrointestinal oncology · 2024Article
- The Role of Intraoperative and Early Postoperative Blood Pressure Variations, Fluid Balance and Inotropics in Fibula Free Flap Head and Neck Reconstruction: A Retrospective Analysis.Journal of clinical medicine · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative delirium (POD) is a serious complication in patients undergoing microvascular head and neck reconstruction. Whether intraoperative and postoperative blood pressure regulation are risk factors for POD remains unclear. This study aimed to highlight the relationships between intraoperative and postoperative blood pressure regulation and POD in microvascular head and neck reconstruction.
methodsData from 433 patients who underwent microvascular head and neck reconstruction at our department of oral and maxillofacial surgery between 2011 and 2019 were retrospectively analyzed. The 55 patients with POD were matched with 55 patients without POD in terms of tracheotomy, flap type, and flap location, and the intraoperative and postoperative systolic and mean blood pressure values were compared between the two groups.
resultsPatients with POD showed lower intraoperative and postoperative minimum mean arterial pressure (MAP) values than patients without POD (60.0 mmHg vs. 65.0 mmHg, p < 0.001; and 56.0 mmHg vs. 62.0 mmHg, p < 0.001; respectively). A lower intraoperative minimum MAP value was identified as predictor for POD (odds ratio [OR] 1.246, 95% confidence interval [CI] 1.057-1.472, p = 0.009). The cut-off value for intraoperative MAP for predicting POD was ≤ 62.5 mmHg (area under the curve [AUC] 0.822, 95% CI 0.744-0.900, p < 0.001).
conclusionsMaintaining a stable intraoperative minimum MAP of > 62.5 mmHg could help to reduce the incidence of POD in microvascular head and neck reconstruction.
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