Evidence map›Paper›PMID 37736619›Full record

ArticleChemical science2023

Continuous addition kinetic elucidation: catalyst and reactant order, rate constant, and poisoning from a single experiment.

Peter J H Williams, Charles Killeen, Ian C Chagunda, Brett Henderson, Sofia Donnecke, Wil Munro, Jaspreet Sidhu, Denaisha Kraft, David A Harrington, J Scott McIndoe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peter J H WilliamsDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada mcindoe@uvic.ca +1 250 721-7166.
Charles KilleenDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada mcindoe@uvic.ca +1 250 721-7166.
Ian C ChagundaDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada mcindoe@uvic.ca +1 250 721-7166.ORCID https://orcid.org/0000-0003-0578-9701
Brett HendersonDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada mcindoe@uvic.ca +1 250 721-7166.
Sofia DonneckeDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada mcindoe@uvic.ca +1 250 721-7166.
Wil MunroDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada mcindoe@uvic.ca +1 250 721-7166.
Jaspreet SidhuDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada mcindoe@uvic.ca +1 250 721-7166.
Denaisha KraftDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada mcindoe@uvic.ca +1 250 721-7166.
David A HarringtonDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada dharr@uvic.ca +1 250 721-7166.ORCID https://orcid.org/0000-0002-9901-6795
J Scott McIndoeDepartment of Chemistry, University of Victoria PO Box 1700 STN CSC Victoria BC V8W 2Y2 Canada mcindoe@uvic.ca +1 250 721-7166.ORCID https://orcid.org/0000-0001-7073-5246

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kinetic analysis of catalytic reactions is a powerful tool for mechanistic elucidation but is often challenging to perform, limiting understanding and therefore development of these reactions. Establishing order in a catalyst is usually achieved by running several reactions at different loadings, which is both time-consuming and complicated by the challenge of maintaining consistent run-to-run experimental conditions. Continuous addition kinetic elucidation (CAKE) was developed to circumvent these issues by continuously injecting a catalyst into a reaction, while monitoring reaction progress over time. For reactions that are

Identifiers

PMID37736619
PMCPMC10510844

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.