ReviewInternational journal of physiology, pathophysiology and pharmacology2023
Obstructive sleep apnea and epilepsy: understanding the pathophysiology of the comorbidity.
Review in International journal of physiology, pathophysiology and pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 12 citations in OpenAlex.
- Clinical Characteristics, Treatment Patterns, and Drug-Resistant Epilepsy Among Emirati Adults with Epilepsy.Neurology and therapy · 2026Article
- Effects of pulvinar and combined pulvinar/anterior thalamic deep-brain stimulation on sleep: preliminary results.Journal of neurology · 2026Article
- Age-Related Characteristics of SYT1-Associated Neurodevelopmental Disorder.Annals of clinical and translational neurology · 2026Article
- Narcolepsy-like presentations in intellectual disability with comorbid epilepsy and obstructive sleep apnea: a case-based diagnostic analysis and literature-informed discussion.Frontiers in psychiatry · 2026Article
- Sleep Traits and Risk of Epilepsy: A Bidirectional and Multivariable Two-Sample Mendelian Randomization Study.Yonsei medical journal · 2025Article
- Refuting a Temporal Correlation: Interictal Epileptic Discharges Do Not Preferentially Occur During Respiratory Events in Patients With Sleep-Related Breathing Disorder and Epilepsy.Journal of sleep research · 2025Article
- Kaptin-Actin Binding Protein (KPTN)-Related Disorder: A Case Report of Two Siblings Harboring a Novel KPTN Mutation.Cureus · 2025Article
- Epilepsy in Autism: Prevalence and Associated Factors in a Large Inpatient Psychiatric Sample.Journal of autism and developmental disorders · 2025Article
- Depression in older adults with epilepsy: Pathophysiology and management considerations.Epilepsy & behavior : E&B · 2025Review
- Sleep Deprivation Increases Mortality Risk Among Older Adults with Epilepsy.Healthcare (Basel, Switzerland) · 2025Article
- High prevalence of epilepsy in pediatric patients with obstructive sleep apnea-a large-scale cross-sectional study.European journal of pediatrics · 2025Article
- Recurrent obstructive sleep apnea precipitated by vagus nerve stimulator despite weight loss and uvulopalatopharyngoplasty.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- The association between epilepsy and sleep disturbance in US adults: the mediating effect of depression.BMC public health · 2024Article
- Article
- Syncope vs. Seizure: Ictal Bradycardia and Ictal Asystole.Case reports in neurological medicine · 2024Article
- Mapping the comorbidome: A novel analysis of the associations between obstructive sleep apnea and its comorbidities in Colombia.Science progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnea (OSA) is a sleep disorder of significant health concern with a high prevalence in the general population. It has been found to exhibit a high incidence of comorbidity with epilepsy, the exact underlying pathophysiology of which still remains poorly understood. OSA is characterized by apnea/hypopnea spells and arousals, leading to intermittent hypoxemia and sleep deprivation. Both sleep deprivation and hypoxemia adversely affect the cortical excitability and favor epileptogenesis and worsening of pre-existing epilepsy, if any. In patients with OSA, deprivation of rapid eye movement sleep (REMS) phase (known for its strong antiepileptic influence) is relatively more than that non rapid eye movement sleep phase leading to postulation of REMS deprivation as a significant factor in the development of epilepsy as a comorbidity in patients with OSA. Furthermore, OSA and epilepsy both have shown to exercise a bidirectional influence on one another and are also likely to exacerbate each other through a positive feedback mechanism. This is especially based on the reports of improved control of epilepsy upon treatment of comorbid OSA. This brief paper attempts to present an underlying pathophysiological basis of the comorbidity of OSA and epilepsy based upon sleep deprivation and hypoxemia that are characteristic features observed in patients with OSA.
Indexed as
Identifiers
37736503PMC10509561W4386945266What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.