Evidence map›Paper›PMID 37736389›Full record

ArticleInternational journal of biochemistry and molecular biology2023

Apolipoprotein M gene polymorphisms in childhood-onset type 1 diabetes in southern Brazil.

Susan Webber de Souza, Mateus Santana Lopes, Bruna Rodrigues Martins, Manoella Abrão da Costa, Suzana Nesi-França, Graciele Cristiane More Manica, Angelica Beate Winter Boldt, Alexessander Couto Alves, Vivian Rotuno Moure, Glaucio Valdameri and 2 more

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In one paragraph

Article in International journal of biochemistry and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Susan Webber de SouzaDepartment of Clinical Analysis, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Parana Curitiba, PR, Brazil.
Mateus Santana LopesDepartment of Clinical Analysis, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Parana Curitiba, PR, Brazil.
Bruna Rodrigues MartinsDepartment of Clinical Analysis, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Parana Curitiba, PR, Brazil.
Manoella Abrão da CostaDepartment of Clinical Analysis, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Parana Curitiba, PR, Brazil.
Suzana Nesi-FrançaPediatric Endocrinology Unit, Department of Pediatrics, Federal University of Parana Curitiba, PR, Brazil.
Graciele Cristiane More ManicaDepartment of Clinical Analysis, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Parana Curitiba, PR, Brazil.
Angelica Beate Winter BoldtPostgraduate Program in Genetics, Department of Genetics, Federal University of Parana Curitiba, PR, Brazil.
Alexessander Couto AlvesSchool of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey Guildford, Surrey, UK.
Vivian Rotuno MoureDepartment of Clinical Analysis, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Parana Curitiba, PR, Brazil.
Glaucio ValdameriDepartment of Clinical Analysis, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Parana Curitiba, PR, Brazil.
Geraldo PichethDepartment of Clinical Analysis, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Parana Curitiba, PR, Brazil.
Fabiane Gomes de Moraes RegoDepartment of Clinical Analysis, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Parana Curitiba, PR, Brazil.
Universidade Federal do Paraná · BRUniversity of Surrey · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes mellitus (T1DM), associated with autoimmune destruction of pancreatic β cells, is observed in children and adolescents.

objectiveWe investigated the potential association of the apolipoprotein M (

methodsThis project was approved by the Ethics Committee of the Federal University of Parana (CAAE 24676613.6.0000.0102). Genotyping was performed using PCR-restriction fragment length polymorphisms (rs805296 and rs9404941) and TaqMan probes (rs707921, rs805264, and rs805297).

resultsAll polymorphisms were in Hardy-Weinberg equilibrium. In the codominant model, no significant differences (

conclusionsHaplotype analysis suggests that rs805297-C, rs9404941-T, rs805296-T, rs805264-G, and rs707921-C conferred risk (OR: 4.25; 95% CI: 1.81-10.1) to childhood-onset T1DM in the Euro-Brazilian population.

Indexed as

APOM genechildhood-onset diabetesDiabetes mellitusEuro-Brazilianpolymorphism

Identifiers

PMID37736389
PMCPMC10509533
OpenAlexW4386944992

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.