Evidence map›Paper›PMID 37736370›Full record

ArticlePediatric investigation2023

Application of topical gentamicin ointment in the treatment of Nagashima-type palmoplantar keratosis in children with a nonsense mutation.

Shan Wang, Zhou Yang, Ying Liu, Huan Zhang, Zongyang Liu, Xiaoling Wang, Ying Li, Haihong Liu, Yonghong Yang, Lin Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Palmoplantar Keratoderma: A Mechanism-Based Disease Classification.Clinical, cosmetic and investigational dermatology · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shan WangDepartment of Dermatology, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China.ORCID https://orcid.org/0000-0003-2177-5318
Zhou YangDepartment of Dermatology, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China.ORCID https://orcid.org/0000-0002-2989-3215
Ying LiuDepartment of Dermatology, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China.ORCID https://orcid.org/0000-0003-4224-5076
Huan ZhangDepartment of Pharmacy, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China.
Zongyang LiuDepartment of Pharmacy, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China.
Xiaoling WangDepartment of Pharmacy, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China.
Ying LiDepartment of Otolaryngology, Head and Neck Surgery Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing China.
Haihong LiuDepartment of Otolaryngology, Head and Neck Surgery Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing China.
Yonghong YangDepartment of Respiratory Medicine China National Clinical Research Center for Respiratory Diseases Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing China.
Lin MaDepartment of Dermatology, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China.ORCID https://orcid.org/0000-0001-7625-9842
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Nagashima-type palmoplantar keratosis (NPPK) is a hereditary dermatosis mostly caused by a nonsense mutation in Objective: This study aimed to provide further evidence for the use of topical gentamicin in the treatment of NPPK in children with nonsense mutations. Methods: We designed a bilaterally controlled study of topical gentamicin ointment. Children diagnosed with NPPK carrying nonsense mutations were enrolled in this study. A 0.1% gentamicin ointment was applied to one hand and an emollient to the other for 3 months. A bilateral comparison of the visual analog scale scores for clinical manifestations and safety was performed. Results: Ten children with NPPK were included in this study. In comparison with the emollient side, the topical gentamicin side showed significant improvements in hyperkeratosis, erythema, maceration, and desquamation after 1 and 3 months of treatment ( Interpretation: Topical gentamicin ointment showed good safety in the treatment of NPPK with nonsense mutations, indicating that it is a promising therapeutic choice in children with NPPK.

Indexed as

ChildrenGentamicinNagashima‐type palmoplantar keratosisNonsense mutationReadthrough treatment

Identifiers

PMID37736370
PMCPMC10509405
OpenAlexW4382468056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.