Evidence map›Paper›PMID 37736312›Full record

ArticleJournal of biomedical optics2023

Fluorescence-guided surgical system using holographic display: from phantom studies to canine patients.

Mebin B George, Benjamin Lew, Zuodong Liang, Steven Blair, Zhongmin Zhu, Nan Cui, Jamie Ludwig, Mohamed Zayed, Laura Selmic, Viktor Gruev

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Design and evaluation of an AR-based thermal imaging system for planning reconstructive surgeries.International journal of computer assisted radiology and surgery · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mebin B GeorgeUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois, United States.ORCID 0000-0002-5531-7721
Benjamin LewUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois, United States.ORCID 0000-0002-4555-0378
Zuodong LiangUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois, United States.
Steven BlairUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois, United States.ORCID 0000-0002-2505-6866
Zhongmin ZhuUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois, United States.ORCID 0000-0003-0158-7168
Nan CuiUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois, United States.
Jamie LudwigUniversity of Illinois at Urbana-Champaign, Division of Animal Resources, Urbana, Illinois, United States.
Mohamed ZayedWashington University in St. Louis, Department of Surgery, St. Louis, Missouri, United States.
Laura SelmicOhio State University, Department of Veterinary Clinical Sciences, Columbus, Ohio, United States.ORCID 0000-0001-6695-6273
Viktor GruevUniversity of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois, United States.

Funding

Shared Resource - Core A: Administrative CoreP01CA254859 · NCI · UNIVERSITY OF PENNSYLVANIA · PI EDWARD J DELIKATNY · 2022 to 2026
$10.0M
Regulation of Endothelial Lipid Metabolism in the Setting of Diabetes and Critical Limb Ischemia to Prevent Surgical ComplicationsR01HL153262 · NHLBI · WASHINGTON UNIVERSITY · PI ZAYED, MOHAMED A. · 2021 to 2024
$2.1M
NCI NIH HHS P01 CA254859NHLBI NIH HHS R01 HL153262
6 · The paper itself

Abstract

Significance: Holographic display technology is a promising area of research that can lead to significant advancements in cancer surgery. We present the benefits of combining bioinspired multispectral imaging technology with holographic goggles for fluorescence-guided cancer surgery. Through a series of experiments with 43D-printed phantoms, small animal models of cancer, and surgeries on canine patients with head and neck cancer, we showcase the advantages of this holistic approach. Aim: The aim of our study is to demonstrate the feasibility and potential benefits of utilizing holographic display for fluorescence-guided surgery through a series of experiments involving 3D-printed phantoms and canine patients with head and neck cancer. Approach: We explore the integration of a bioinspired camera with a mixed reality headset to project fluorescent images as holograms onto a see-through display, and we demonstrate the potential benefits of this technology through benchtop and Results: Our complete imaging and holographic display system showcased improved delineation of fluorescent targets in phantoms compared with the 2D monitor display approach and easy integration into the veterinarian surgical workflow. Conclusions: Based on our findings, it is evident that our comprehensive approach, which combines a bioinspired multispectral imaging sensor with holographic goggles, holds promise in enhancing the presentation of fluorescent information to surgeons during intraoperative scenarios while minimizing disruptions.

Indexed as

HolographySurgeonsSurgery, Computer-AssistedAnimalsColoring AgentsDogsHumansPhantoms, ImagingColoring Agentsbioinspired sensorscancer surgeryfluorescence guided surgerygogglesholographic displays

Identifiers

PMID37736312
PMCPMC10509484

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.