ReviewClinical ophthalmology (Auckland, N.Z.)2023
Keratoconus Diagnosis and Treatment: Recent Advances and Future Directions.
Review in Clinical ophthalmology (Auckland, N.Z.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Early Detection of Keratoconus: Diagnostic Advances and Their Impact on Visual Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- The candidate proteins associated with keratoconus: A meta-analysis and bioinformatic analysis.PloS one · 2024Pooled it
- Utility of artificial intelligence in the diagnosis and management of keratoconus: a systematic review.Frontiers in ophthalmology · 2024Pooled it
- Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.Ophthalmology and therapy · 2026Review
- Smartphone-Assisted Placido Ring Imaging for K1 Stratification in Keratoconus: A Deep Learning Study.Diagnostics (Basel, Switzerland) · 2026Article
- Characteristics and Prediction Accuracy According to Corneal Stiffness in Suspected Keratoconus.Journal of clinical medicine · 2026Article
- Long-term impact of scleral contact lens use on endothelial cell density in patients with moderate to advanced keratoconus.BMC ophthalmology · 2026Article
- The Corvis ST analysis of underaged versus adults' healthy eyes with comparable tomography detects softer corneas in children and adolescents as opposed to adults.Scientific reports · 2026Article
- Postoperative Pain and Functional Limitations After Corneal Cross-Linking for Keratoconus: A Patient-Reported Outcome Study.Life (Basel, Switzerland) · 2026Article
- Demographic and clinical presentations of keratoconus in Trinidad and Tobago: a retrospective study.BMC ophthalmology · 2026Article
- Deep-stromal implantation of a double-crosslinked bioengineered porcine collagen implant (BPCDX) in advanced keratoconus: a 12-month study of corneal remodeling and visual outcomes.Scientific reports · 2026Article
- Prevalence and Risk Factors for Keratoconus in Young Adults Assessed with Tomography and Corneal Biomechanics: A Prospective Cross-Sectional Study.Ophthalmology science · 2026Article
- The Critical Role of Oxygen Supplementation in Epithelium-On Corneal Cross-Linking: A Narrative Review.Advances in therapy · 2026Review
- Tannic Acid Achieves Rapid Scar-Free Corneal Healing by Chelating Excess Copper to Suppress Aberrant LOX-Mediated Fibrosis.Investigative ophthalmology & visual science · 2026Article
- Data-Driven Detection of Subclinical Keratoconus via Semi-Supervised Clustering of Multidimensional Corneal Biomarkers.Ophthalmology science · 2026Article
- Vision-Related Quality of Life in Iraqi Keratoconus Patients: A Comparative Analysis of Surgical and Nonsurgical Interventions.Korean journal of ophthalmology : KJO · 2026Article
- Corneal Cross-Linking in Keratoconus: Comparative Analysis of Standard, Accelerated and Transepithelial Protocols.Journal of clinical medicine · 2026Review
- The Genetic and Epigenetic Architecture of Keratoconus: Emerging Pathways and Clinical Implications.Genes · 2026Review
- In Vivo Biomechanical Characteristics of Human Corneas With Phase-Decorrelation OCT.Investigative ophthalmology & visual science · 2026Article
- Evaluating corneal topographic patterns in keratoconic eyes and their association with keratoconus changes over time.International journal of ophthalmology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Keratoconus is a disorder characterized by progressive corneal thinning and steepening that may result in significant visual impairment secondary to high astigmatism, corneal scarring, or even corneal perforation. Early detection and screening of keratoconus are essential for effective management and treatment. Several screening methods, such as corneal topography and tomography, corneal biomechanics, and genetic testing, are being developed to detect keratoconus at an early stage. Once detected, prevention of progression is the mainstay of keratoconus management. Corneal collagen cross-linking is a minimally invasive treatment option that can slow or halt the progression of keratoconus. Additionally, recent studies have investigated the potential use of copper sulfate eye drops (IVMED-80) and extracellular vesicles to prevent the progression of keratoconus as non-invasive treatment options. For visual rehabilitation, currently available treatments include scleral lenses, intracorneal ring segments, corneal allogenic intrastromal ring segments, and deep anterior lamellar keratoplasty. The safety and efficacy of these emerging treatment options for keratoconus are currently being investigated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.