Evidence map›Paper›PMID 37736075›Full record

ArticleAmerican journal of clinical and experimental immunology2023

Androgen receptor signaling protects male mice from the development of immune response to peanut.

Sunanda Rajput, McKenna S Vininski, Leigh-Anne Lehmann, Nicholas J Hobbs, Joseph J Dolence

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of clinical and experimental immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. An Exploratory Analysis of Transcriptional Responses to Peanut Exposure inInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sunanda RajputDepartment of Biology, University of Nebraska at Kearney Kearney, NE, USA.
McKenna S VininskiDepartment of Biology, University of Nebraska at Kearney Kearney, NE, USA.
Leigh-Anne LehmannDepartment of Biology, University of Nebraska at Kearney Kearney, NE, USA.
Nicholas J HobbsDepartment of Biology, University of Nebraska at Kearney Kearney, NE, USA.
Joseph J DolenceDepartment of Biology, University of Nebraska at Kearney Kearney, NE, USA.
University of Nebraska at Kearney · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
NIGMS NIH HHS P20 GM103427
6 · The paper itself

Abstract

objectivesPeanut (PN) allergy is a major public health concern. Recent research has brought clarity about how individuals become sensitized to PN allergen with routes known through the skin, as well as the airway. Still unclear, however, is the role of sex hormones on the development of allergic immune responses to PN. This study examines the role of androgen receptor (AR) signaling in regulating PN-specific immune responses.

methodsWe utilized a 4-week inhalation mouse model of PN allergy that is known to drive the production of PN-specific antibodies and elicit systemic anaphylaxis following PN challenge. Wildtype (WT) male, female, and androgen receptor-deficient testicular feminization mutant (AR

resultsAR use is critical in regulating PN-specific antibody levels. We found that AR

conclusionsTaken together, this study suggests that male sex hormones, namely androgens, negatively regulate allergic immune responses to PN.

Indexed as

androgen receptorARTfm (androgen receptor-deficient) malegroup 2 innate lymphoid cells (ILC2s)Peanut (PN) allergyPN-specific antibodiessystemic anaphylaxis

Identifiers

PMID37736075
PMCPMC10509486
OpenAlexW4386945221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.