Evidence map›Paper›PMID 37736049›Full record

ArticleiScience2023

Colitis-induced upregulation of tumor necrosis factor receptor-2 (TNFR2) terminates epithelial regenerative signaling to restore homeostasis.

Zohreh Sharifkhodaei, Cambrian Y Liu, Nandini Girish, Ying Huang, Shivesh Punit, M Kay Washington, D Brent Polk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Interferon-gamma signaling drives epithelial TNF-alpha receptor-2 expression during colonic tissue repair.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Zohreh SharifkhodaeiDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Cambrian Y LiuDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Nandini GirishDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Ying HuangThe Saban Research Institute, Division of Pediatric Gastroenterology, Hepatology Nutrition, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Shivesh PunitThe Saban Research Institute, Division of Pediatric Gastroenterology, Hepatology Nutrition, Children's Hospital Los Angeles, Los Angeles, CA, USA.
M Kay WashingtonDepartment of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA.
D Brent PolkDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
University of California, San Diego · USChildren's Hospital of Los Angeles · USUniversity of Chicago · USVanderbilt University Medical Center · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
CYTOKINE REGULATION OF INTESTINAL EPITHELIAL RESTITUTIONR01DK056008 · NIDDK · VANDERBILT UNIVERSITY · PI POLK, D BRENT · 1999 to 2020
$6.8M
Stem Cell Dynamics in Colonic Epithelial RepairR01DK108648 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Cambrian Yangshao Liu, D Brent Polk · 2016 to 2026
$2.7M
Colonic epithelial wound healing by anal transitional cellsR01DK135954 · NIDDK · UNIVERSITY OF CHICAGO · PI Cambrian Yangshao Liu · 2023 to 2026
$2.2M
Probing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeuticsR01DK138072 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Kristina Brooke Martinez-Guryn · 2024 to 2026
$2.1M
NIDDK NIH HHS P30 DK042086NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK056008NIDDK NIH HHS R01 DK108648NIDDK NIH HHS R01 DK135954NIDDK NIH HHS R01 DK138072
6 · The paper itself

Abstract

Colonic epithelial repair is a key determinant of health. Repair involves changes in epithelial differentiation, an extensive proliferative response, and upregulation of regeneration-associated "fetal-like" transcripts, including

Indexed as

Cell biologyImmunologyMolecular biologyOmicsPhysiologyTranscriptomics

Identifiers

PMID37736049
PMCPMC10510063
OpenAlexW4386418525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.